ID   SIVA_RAT                Reviewed;         177 AA.
AC   P59692;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Apoptosis regulatory protein Siva;
DE   AltName: Full=CD27-binding protein;
DE            Short=CD27BP;
GN   Name=Siva1; Synonyms=Siva;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX   PubMed=9853261; DOI=10.1046/j.1523-1755.1998.00197.x;
RA   Padanilam B.J., Lewington A.J.P., Hammerman M.R.;
RT   "Expression of CD27 and ischemia/reperfusion-induced expression of its
RT   ligand Siva in rat kidneys.";
RL   Kidney Int. 54:1967-1975(1998).
CC   -!- FUNCTION: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-
CC       x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and
CC       promotes T-cell receptor-mediated apoptosis (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 3 Zn(2+) ions. {ECO:0000250};
CC   -!- SUBUNIT: Binds through its N-terminal region to the C-terminus of CD27
CC       and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Binds to
CC       BCL2L1/BCLX isoform Bcl-x(L) but not to BAX (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=In the nucleus, accumulates in dot-like structures. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: In post-ischemic kidney, found in cells lining the
CC       S3 segment of proximal tubules at 12 hours and 1 day post-ischemia. At
CC       five and seven days post-ischemia, found in epithelial cells of
CC       papillary proliferations in regenerating tubules.
CC       {ECO:0000269|PubMed:9853261}.
CC   -!- INDUCTION: By ischemia. {ECO:0000269|PubMed:9853261}.
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DR   RefSeq; XP_006240707.1; XM_006240645.3.
DR   AlphaFoldDB; P59692; -.
DR   STRING; 10116.ENSRNOP00000034257; -.
DR   PaxDb; P59692; -.
DR   Ensembl; ENSRNOT00000031788; ENSRNOP00000034257; ENSRNOG00000028640.
DR   GeneID; 362791; -.
DR   UCSC; RGD:1561872; rat.
DR   CTD; 10572; -.
DR   RGD; 1561872; Siva1.
DR   eggNOG; ENOG502S2B7; Eukaryota.
DR   GeneTree; ENSGT00390000004842; -.
DR   HOGENOM; CLU_127299_0_0_1; -.
DR   InParanoid; P59692; -.
DR   OMA; FRGAQAC; -.
DR   OrthoDB; 1386185at2759; -.
DR   PhylomeDB; P59692; -.
DR   TreeFam; TF332962; -.
DR   PRO; PR:P59692; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000028640; Expressed in thymus and 19 other tissues.
DR   ExpressionAtlas; P59692; baseline and differential.
DR   Genevisible; P59692; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005175; F:CD27 receptor binding; ISO:RGD.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; ISO:RGD.
DR   GO; GO:0001618; F:virus receptor activity; ISO:RGD.
DR   GO; GO:0008270; F:zinc ion binding; ISO:RGD.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:RGD.
DR   InterPro; IPR022773; Siva.
DR   PANTHER; PTHR14365; PTHR14365; 1.
DR   Pfam; PF05458; Siva; 1.
DR   PIRSF; PIRSF038096; Siva_cd27_bd; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Zinc.
FT   CHAIN           1..177
FT                   /note="Apoptosis regulatory protein Siva"
FT                   /id="PRO_0000097776"
FT   REGION          36..55
FT                   /note="Interaction with BCL2L1 isoform Bcl-x(L) and
FT                   inhibition of BCL2L1 anti-apoptotic activity"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         34
FT                   /note="Phosphotyrosine; by ABL2"
FT                   /evidence="ECO:0000250|UniProtKB:O15304"
SQ   SEQUENCE   177 AA;  18899 MW;  4372588F50FF5DEE CRC64;
     MPKRSCPFTD AAPLQLKVHV SPRELSHGVF AERYSREVFE RTKQLLFQGA QAYRDHIWGE
     GCSINHLPEP LKPGLVGAPQ AARGQMLIGP DGRLTRCQAQ ASEAGLPGAA PIACSSCVRS
     VDGKAVCSQC ERALCGQCVY TCWGCGALAC VLCGLADYAD DDDGEKTLCT SCAMFEA