位置:首页 > 蛋白库 > SIX1_GORGO
SIX1_GORGO
ID   SIX1_GORGO              Reviewed;         284 AA.
AC   A1YER0;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Homeobox protein SIX1;
DE   AltName: Full=Sine oculis homeobox homolog 1;
GN   Name=SIX1;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that is involved in the regulation of
CC       cell proliferation, apoptosis and embryonic development (By
CC       similarity). Plays an important role in the development of several
CC       organs, including kidney, muscle and inner ear (By similarity).
CC       Depending on context, functions as transcriptional repressor or
CC       activator (By similarity). Lacks an activation domain, and requires
CC       interaction with EYA family members for transcription activation (By
CC       similarity). Mediates nuclear translocation of EYA1 and EYA2 (By
CC       similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3
CC       element in the MYOG promoter and CIDEA enhancer (By similarity).
CC       Regulates the expression of numerous genes, including MYC, CCNA1, CCND1
CC       and EZR (By similarity). Acts as activator of the IGFBP5 promoter,
CC       probably coactivated by EYA2 (By similarity). Repression of precursor
CC       cell proliferation in myoblasts is switched to activation through
CC       recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During
CC       myogenesis, seems to act together with EYA2 and DACH2 (By similarity).
CC       Regulates the expression of CCNA1 (By similarity). Promotes brown
CC       adipocyte differentiation (By similarity).
CC       {ECO:0000250|UniProtKB:Q15475, ECO:0000250|UniProtKB:Q62231}.
CC   -!- SUBUNIT: Interacts with DACH1 (By similarity). Interacts with EYA1 (By
CC       similarity). Interacts with EYA2 (By similarity). Interacts with CDH1
CC       (By similarity). Interacts with TBX18 (By similarity). Interacts with
CC       CEBPA (By similarity). Interacts with CEBPB (By similarity). Interacts
CC       with EBF2 (By similarity). {ECO:0000250|UniProtKB:Q15475,
CC       ECO:0000250|UniProtKB:Q62231}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC       Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated during interphase; becomes hyperphosphorylated
CC       during mitosis. Hyperphosphorylation impairs binding to promoter
CC       elements (By similarity). {ECO:0000250}.
CC   -!- PTM: Ubiquitinated by the anaphase promoting complex (APC), leading to
CC       its proteasomal degradation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ976442; ABM46628.1; -; Genomic_DNA.
DR   RefSeq; XP_004055308.1; XM_004055260.2.
DR   AlphaFoldDB; A1YER0; -.
DR   SMR; A1YER0; -.
DR   STRING; 9593.ENSGGOP00000001372; -.
DR   Ensembl; ENSGGOT00000001397; ENSGGOP00000001372; ENSGGOG00000001388.
DR   GeneID; 101128790; -.
DR   KEGG; ggo:101128790; -.
DR   CTD; 6495; -.
DR   eggNOG; KOG0775; Eukaryota.
DR   GeneTree; ENSGT00940000156487; -.
DR   HOGENOM; CLU_046914_2_0_1; -.
DR   InParanoid; A1YER0; -.
DR   OMA; TPDHTSM; -.
DR   OrthoDB; 1061244at2759; -.
DR   Proteomes; UP000001519; Chromosome 14.
DR   Bgee; ENSGGOG00000001388; Expressed in testis and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR   GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISS:UniProtKB.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISS:UniProtKB.
DR   GO; GO:0030855; P:epithelial cell differentiation; ISS:UniProtKB.
DR   GO; GO:0048699; P:generation of neurons; ISS:UniProtKB.
DR   GO; GO:0048839; P:inner ear development; ISS:UniProtKB.
DR   GO; GO:0042472; P:inner ear morphogenesis; ISS:UniProtKB.
DR   GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR   GO; GO:0072172; P:mesonephric tubule formation; ISS:UniProtKB.
DR   GO; GO:0072075; P:metanephric mesenchyme development; ISS:UniProtKB.
DR   GO; GO:0051451; P:myoblast migration; ISS:UniProtKB.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0001759; P:organ induction; ISS:UniProtKB.
DR   GO; GO:0007389; P:pattern specification process; ISS:UniProtKB.
DR   GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR   GO; GO:0090336; P:positive regulation of brown fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0072107; P:positive regulation of ureteric bud formation; ISS:UniProtKB.
DR   GO; GO:0072095; P:regulation of branch elongation involved in ureteric bud branching; ISS:UniProtKB.
DR   GO; GO:0045664; P:regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0014857; P:regulation of skeletal muscle cell proliferation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IBA:GO_Central.
DR   GO; GO:0007519; P:skeletal muscle tissue development; ISS:UniProtKB.
DR   GO; GO:0048538; P:thymus development; ISS:UniProtKB.
DR   GO; GO:0030878; P:thyroid gland development; ISS:UniProtKB.
DR   GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR031278; SIX1.
DR   InterPro; IPR031701; SIX1_SD.
DR   PANTHER; PTHR10390:SF13; PTHR10390:SF13; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF16878; SIX1_SD; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Activator; Apoptosis; Cytoplasm; Developmental protein; DNA-binding;
KW   Homeobox; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Ubl conjugation.
FT   CHAIN           1..284
FT                   /note="Homeobox protein SIX1"
FT                   /id="PRO_0000285458"
FT   DNA_BIND        124..183
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          168..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   284 AA;  32210 MW;  A4195376CFB9E3EA CRC64;
     MSMLPSFGFT QEQVACVCEV LQQGGNLERL GRFLWSLPAC DHLHKNESVL KAKAVVAFHR
     GNFRELYKIL ESHQFSPHNH PKLQQLWLKA HYVEAEKLRG RPLGAVGKYR VRRKFPLPRT
     IWDGEETSYC FKEKSRGVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR
     AAEAKERENT ENNNSSSNKQ NQLSPLEGGK PLMSSSEEEF SPPQSPDQNS VLLLQGNMGH
     ARSSNYSLPG LTASQPSHGL QTHQHQLQDS LLGPLTSSLV DLGS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024