SIX1_LAGLA
ID SIX1_LAGLA Reviewed; 284 AA.
AC A2D5H2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Homeobox protein SIX1;
DE AltName: Full=Sine oculis homeobox homolog 1;
GN Name=SIX1;
OS Lagothrix lagotricha (Brown woolly monkey) (Humboldt's woolly monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Atelidae;
OC Atelinae; Lagothrix.
OX NCBI_TaxID=9519;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT "Positive selection in transcription factor genes on the human lineage.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that is involved in the regulation of
CC cell proliferation, apoptosis and embryonic development (By
CC similarity). Plays an important role in the development of several
CC organs, including kidney, muscle and inner ear (By similarity).
CC Depending on context, functions as transcriptional repressor or
CC activator (By similarity). Lacks an activation domain, and requires
CC interaction with EYA family members for transcription activation (By
CC similarity). Mediates nuclear translocation of EYA1 and EYA2 (By
CC similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3
CC element in the MYOG promoter and CIDEA enhancer (By similarity).
CC Regulates the expression of numerous genes, including MYC, CCNA1, CCND1
CC and EZR (By similarity). Acts as activator of the IGFBP5 promoter,
CC probably coactivated by EYA2 (By similarity). Repression of precursor
CC cell proliferation in myoblasts is switched to activation through
CC recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During
CC myogenesis, seems to act together with EYA2 and DACH2 (By similarity).
CC Regulates the expression of CCNA1 (By similarity). Promotes brown
CC adipocyte differentiation (By similarity).
CC {ECO:0000250|UniProtKB:Q15475, ECO:0000250|UniProtKB:Q62231}.
CC -!- SUBUNIT: Interacts with DACH1 (By similarity). Interacts with EYA1 (By
CC similarity). Interacts with EYA2 (By similarity). Interacts with CDH1
CC (By similarity). Interacts with TBX18 (By similarity). Interacts with
CC CEBPA (By similarity). Interacts with CEBPB (By similarity). Interacts
CC with EBF2 (By similarity). {ECO:0000250|UniProtKB:Q15475,
CC ECO:0000250|UniProtKB:Q62231}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15475}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q15475}.
CC -!- PTM: Phosphorylated during interphase; becomes hyperphosphorylated
CC during mitosis. Hyperphosphorylation impairs binding to promoter
CC elements (By similarity). {ECO:0000250}.
CC -!- PTM: Ubiquitinated by the anaphase promoting complex (APC), leading to
CC its proteasomal degradation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ976721; ABM68164.1; -; Genomic_DNA.
DR AlphaFoldDB; A2D5H2; -.
DR SMR; A2D5H2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISS:UniProtKB.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISS:UniProtKB.
DR GO; GO:0030855; P:epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0048699; P:generation of neurons; ISS:UniProtKB.
DR GO; GO:0048839; P:inner ear development; ISS:UniProtKB.
DR GO; GO:0042472; P:inner ear morphogenesis; ISS:UniProtKB.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0072172; P:mesonephric tubule formation; ISS:UniProtKB.
DR GO; GO:0072075; P:metanephric mesenchyme development; ISS:UniProtKB.
DR GO; GO:0051451; P:myoblast migration; ISS:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0001759; P:organ induction; ISS:UniProtKB.
DR GO; GO:0007389; P:pattern specification process; ISS:UniProtKB.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0090336; P:positive regulation of brown fat cell differentiation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0072107; P:positive regulation of ureteric bud formation; ISS:UniProtKB.
DR GO; GO:0072095; P:regulation of branch elongation involved in ureteric bud branching; ISS:UniProtKB.
DR GO; GO:0045664; P:regulation of neuron differentiation; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007519; P:skeletal muscle tissue development; ISS:UniProtKB.
DR GO; GO:0048538; P:thymus development; ISS:UniProtKB.
DR GO; GO:0030878; P:thyroid gland development; ISS:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR031278; SIX1.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390:SF13; PTHR10390:SF13; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Activator; Apoptosis; Cytoplasm; Developmental protein; DNA-binding;
KW Homeobox; Nucleus; Phosphoprotein; Repressor; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..284
FT /note="Homeobox protein SIX1"
FT /id="PRO_0000285459"
FT DNA_BIND 124..183
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 168..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 284 AA; 32180 MW; 51195376CFB9F8EB CRC64;
MSMLPSFGFT QEQVACVCEV LQQGGNLERL GRFLWSLPAC DHLHKNESVL KAKAVVAFHR
GNFRELYKIL ESHQFSPHNH PKLQQLWLKA HYVEAEKLRG RPLGAVGKYR VRRKFPLPRT
IWDGEETSYC FKEKSRGVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR
AAEAKERENT ENNNSSSNKQ NQLSPLEGGK PLMSSSEEEF SPPQSPDQNS VLLLQGNMGH
ARSSNYSLPG LTASQPSHGL QAHQHQLQDS LLGPLTSSLV DLGS
