ID   SIX1_XENLA              Reviewed;         284 AA.
AC   Q9I8H0;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Homeobox protein six1;
DE   AltName: Full=Sine oculis homeobox homolog 1;
GN   Name=six1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10960794; DOI=10.1016/s0925-4773(00)00396-8;
RA   Pandur P.D., Moody S.A.;
RT   "Xenopus Six1 gene is expressed in neurogenic cranial placodes and
RT   maintained in the differentiating lateral lines.";
RL   Mech. Dev. 96:253-257(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=15525662; DOI=10.1242/dev.01516;
RA   Brugmann S.A., Pandur P.D., Kenyon K.L., Pignoni F., Moody S.A.;
RT   "Six1 promotes a placodal fate within the lateral neurogenic ectoderm by
RT   functioning as both a transcriptional activator and repressor.";
RL   Development 131:5871-5881(2004).
CC   -!- FUNCTION: Transcription factor that is involved in the regulation of
CC       cell proliferation, apoptosis and embryonic development. Depending on
CC       context, functions as transcriptional repressor or activator. Required
CC       for the normal formation of pre-placodal ectoderm.
CC       {ECO:0000269|PubMed:15525662}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15475}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q15475}.
CC   -!- DEVELOPMENTAL STAGE: First detected in gastrula. Prominently expressed
CC       in all neurogenic cephalic placodes and in lateral line primordia from
CC       neurula to tadpole stages. Weakly expressed in muscle later in
CC       development.
CC   -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC       {ECO:0000305}.
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DR   EMBL; AF279254; AAF91422.1; -; mRNA.
DR   EMBL; BC169552; AAI69552.1; -; mRNA.
DR   EMBL; BC169929; AAI69929.1; -; mRNA.
DR   RefSeq; NP_001082027.1; NM_001088558.1.
DR   AlphaFoldDB; Q9I8H0; -.
DR   SMR; Q9I8H0; -.
DR   GeneID; 398185; -.
DR   KEGG; xla:398185; -.
DR   CTD; 398185; -.
DR   Xenbase; XB-GENE-480721; six1.L.
DR   OMA; EVSCICE; -.
DR   OrthoDB; 1061244at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 398185; Expressed in internal ear and 11 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR031278; SIX1.
DR   InterPro; IPR031701; SIX1_SD.
DR   PANTHER; PTHR10390:SF13; PTHR10390:SF13; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF16878; SIX1_SD; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Apoptosis; Cytoplasm; Developmental protein; DNA-binding;
KW   Homeobox; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..284
FT                   /note="Homeobox protein six1"
FT                   /id="PRO_0000422775"
FT   DNA_BIND        124..183
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          168..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   284 AA;  32017 MW;  073FBFC5309964C3 CRC64;
     MSMLPSFGFT QEQVACVCEV LQQGGNLERL GRFLWSLPAC DHLHKNESVL KAKAVVAFHR
     GNFRELYKIL ESHQFSPHNH PKLQQLWLKA HYVEAEKLRG RPLGAVGKYR VRRKFPLPRT
     IWDGEETSYC FKEKSRGVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR
     AAEAKERENT ENNNTSTNKQ NQLSPLDGGK SLMSSSEEEF SPPQSPDQNS VLLLQGSLTH
     PGATSYSLSA LSASQGSHGL QGHQHQLQDS LLGPLTSSLV DLGS