ID   SIXP1_MESMA             Reviewed;          15 AA.
AC   P0C5S7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   23-FEB-2022, entry version 19.
DE   RecName: Full=Insect toxin BmK AngP1;
DE   Flags: Fragment;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND CRYSTALLIZATION.
RC   TISSUE=Venom;
RX   PubMed=11454167; DOI=10.1034/j.1399-3011.2001.00869.x;
RA   Guan R.-J., Wang M., Wang D., Wang D.-C.;
RT   "A new insect neurotoxin AngP1 with analgesic effect from the scorpion
RT   Buthus martensii Karsch: purification and characterization.";
RL   J. Pept. Res. 58:27-35(2001).
CC   -!- FUNCTION: Excitatory insect beta-toxins induce a spastic paralysis.
CC       They bind voltage-independently at site-4 of sodium channels (Nav) and
CC       shift the voltage of activation toward more negative potentials thereby
CC       affecting sodium channel activation and promoting spontaneous and
CC       repetitive firing. This toxin shows an evident analgesic effect on
CC       mice, but is devoid of mammalian toxicity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=8141.0; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11454167};
CC   -!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin superfamily.
CC       Sodium channel inhibitor family. Beta subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..>15
FT                   /note="Insect toxin BmK AngP1"
FT                   /id="PRO_0000310537"
FT   NON_TER         15
SQ   SEQUENCE   15 AA;  1553 MW;  9DC389E9FFCB5A1D CRC64;
     KKNGYAVDSS GKVAE