SIZ1_ORYSJ
ID SIZ1_ORYSJ Reviewed; 875 AA.
AC Q6L4L4; A0A0P0WHD5;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=E3 SUMO-protein ligase SIZ1;
DE EC=2.3.2.-;
DE AltName: Full=E3 SUMO-protein transferase SIZ1 {ECO:0000305};
GN Name=SIZ1; OrderedLocusNames=Os05g0125000, LOC_Os05g03430;
GN ORFNames=OSJNBb0079L11.3;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT "A fine physical map of the rice chromosome 5.";
RL Mol. Genet. Genomics 274:337-345(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP STRUCTURE BY NMR OF 2-105.
RX PubMed=18831036; DOI=10.1002/prot.22243;
RA Suzuki R., Shindo H., Tase A., Kikuchi Y., Shimizu M., Yamazaki T.;
RT "Solution structures and DNA binding properties of the N-terminal SAP
RT domains of SUMO E3 ligases from Saccharomyces cerevisiae and Oryza
RT sativa.";
RL Proteins 75:336-347(2009).
CC -!- FUNCTION: Probable SUMO E3 ligase that may regulate Pi starvation
CC responses. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC -!- INTERACTION:
CC Q6L4L4; Q0JCT1: H3; NbExp=5; IntAct=EBI-7896966, EBI-7896995;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PIAS family. {ECO:0000305}.
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DR EMBL; AC134931; AAT39226.1; -; Genomic_DNA.
DR EMBL; AP008211; BAF16431.1; -; Genomic_DNA.
DR EMBL; AP014961; BAS92058.1; -; Genomic_DNA.
DR EMBL; AK105290; BAG97182.1; -; mRNA.
DR RefSeq; XP_015639641.1; XM_015784155.1.
DR PDB; 2RNO; NMR; -; A=2-105.
DR PDB; 2RSD; NMR; -; A=107-172.
DR PDBsum; 2RNO; -.
DR PDBsum; 2RSD; -.
DR AlphaFoldDB; Q6L4L4; -.
DR BMRB; Q6L4L4; -.
DR SMR; Q6L4L4; -.
DR BioGRID; 806709; 1.
DR IntAct; Q6L4L4; 1.
DR MINT; Q6L4L4; -.
DR STRING; 4530.OS05T0125000-01; -.
DR PaxDb; Q6L4L4; -.
DR PRIDE; Q6L4L4; -.
DR EnsemblPlants; Os05t0125000-01; Os05t0125000-01; Os05g0125000.
DR GeneID; 4337672; -.
DR Gramene; Os05t0125000-01; Os05t0125000-01; Os05g0125000.
DR KEGG; osa:4337672; -.
DR eggNOG; KOG2169; Eukaryota.
DR HOGENOM; CLU_015870_2_0_1; -.
DR InParanoid; Q6L4L4; -.
DR OMA; NSNEMHG; -.
DR OrthoDB; 141085at2759; -.
DR PlantReactome; R-OSA-8879007; Response to cold temperature.
DR UniPathway; UPA00886; -.
DR EvolutionaryTrace; Q6L4L4; -.
DR Proteomes; UP000000763; Chromosome 5.
DR Proteomes; UP000059680; Chromosome 5.
DR Genevisible; Q6L4L4; OS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0061665; F:SUMO ligase activity; IDA:CACAO.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IDA:CACAO.
DR Gene3D; 1.10.720.30; -; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR004181; Znf_MIZ.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF02037; SAP; 1.
DR Pfam; PF02891; zf-MIZ; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR SUPFAM; SSF68906; SSF68906; 1.
DR PROSITE; PS50800; SAP; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS51044; ZF_SP_RING; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Nucleus; Reference proteome; Transferase;
KW Ubl conjugation pathway; Zinc; Zinc-finger.
FT CHAIN 1..875
FT /note="E3 SUMO-protein ligase SIZ1"
FT /id="PRO_0000383459"
FT DOMAIN 12..46
FT /note="SAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
FT ZN_FING 114..169
FT /note="PHD-type"
FT ZN_FING 349..430
FT /note="SP-RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT REGION 796..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 380
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT BINDING 382
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT BINDING 403
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT BINDING 406
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00452"
FT HELIX 2..14
FT /evidence="ECO:0007829|PDB:2RNO"
FT HELIX 17..27
FT /evidence="ECO:0007829|PDB:2RNO"
FT HELIX 35..47
FT /evidence="ECO:0007829|PDB:2RNO"
FT HELIX 61..63
FT /evidence="ECO:0007829|PDB:2RNO"
FT HELIX 65..80
FT /evidence="ECO:0007829|PDB:2RNO"
FT STRAND 95..97
FT /evidence="ECO:0007829|PDB:2RNO"
FT STRAND 128..130
FT /evidence="ECO:0007829|PDB:2RSD"
FT TURN 134..136
FT /evidence="ECO:0007829|PDB:2RSD"
FT STRAND 138..141
FT /evidence="ECO:0007829|PDB:2RSD"
FT TURN 142..144
FT /evidence="ECO:0007829|PDB:2RSD"
FT HELIX 164..170
FT /evidence="ECO:0007829|PDB:2RSD"
SQ SEQUENCE 875 AA; 97018 MW; CFDC20ED6CA70920 CRC64;
MADLVSSCKD KLAYFRIKEL KDILNQLGLP KQGKKQDLID RVLALLTDEQ GQRHHGWGRK
NSLTKEAVAK IVDDTYRKMQ IQCAPDLATR SHSGSDFSFR PIEEAYDSFQ PEAKVRCICS
STMVNDSMIQ CEDQRCQVWQ HLNCVLIPDK PGESAEVPPV FYCELCRLSR ADPFWVTAGN
PLLPVKFVSS GVTNDGTSVP QSVEKSFQLS RSDRETVQRQ EYDLQVWCML LNDKVQFRMQ
WPQYAELHVN GISVRVVTRP GSQLLGINGR DDGPLITTCS REGINKICLS RVDARTFCFG
VRIAKRRTVA QVLNLVPKEA EGESFEHALA RVRRCLGGGD TAENADSDSD LEVVAESVTV
NLRCPNSGSR MRIAGRFKPC IHMGCFDLET FVELNQRSRK WQCPICLKNY SLESLMIDPY
FNRITSLLRN CNEDVNEVDV KPDGSWRVKG DAASRELSQW HMPDGTLCNP KEDVKPAMQN
GNEQMMEGTS DGQKSLKIGI KRNPNGIWEV SSKADDKKPS VVGNRMQNNS GFRALNNIMH
MSNSPTSSYR DGEDPSVNQE SNRHVDLSLN NGNNEFDSFS LNFGQACNTD DRPQQQHNAT
DVIVLSDSDE ENDAMVCPPA VYDNTTTANG SGFPFTTNGI GYTERYQEDA GVGTSGLGLL
SNNVDDFEMN NWQMHSSYQQ PEQGFQFFGN DTDVHNTFVG SHNSFGLAPN DYSLDCNVGV
EEASVTPALS VCRNSNEMHG SLVDNPLALV GDDPSLQIFL PSQPSSVPLQ EELSERANAP
NGVQSDDWIS LTLAAGGGGN EEPAPADVNS QPQIPSTETG IEPLTDAASA FLSTNIERRS
GADLNPRRIE NIFSHPRQPR SVRPRLCLSI DTDSE
