ID   SK1_DELRA               Reviewed;          14 AA.
AC   B3EWM3; B3EWM4;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-JUN-2021, entry version 9.
DE   RecName: Full=Sulfakinin {ECO:0000303|PubMed:20869420, ECO:0000303|PubMed:22848525};
DE   Contains:
DE     RecName: Full=Sulfakinin(6-14) {ECO:0000303|PubMed:20869420, ECO:0000303|PubMed:22848525};
OS   Delia radicum (Cabbage root fly) (Anthomyia brassicae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Anthomyiidae; Anthomyiinae; Delia.
OX   NCBI_TaxID=30064;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT
RP   PHE-14.
RC   TISSUE=Abdominal ganglion {ECO:0000269|PubMed:20869420}, and
RC   Brain {ECO:0000269|PubMed:20869420};
RX   PubMed=20869420; DOI=10.1016/j.peptides.2010.08.028;
RA   Audsley N., Matthews H.J., Down R.E., Weaver R.J.;
RT   "Neuropeptides associated with the central nervous system of the cabbage
RT   root fly, Delia radicum (L).";
RL   Peptides 32:434-440(2011).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MASS
RP   SPECTROMETRY, AND AMIDATION AT PHE-14.
RC   TISSUE=CNS {ECO:0000269|PubMed:22848525};
RX   PubMed=22848525; DOI=10.1371/journal.pone.0041543;
RA   Zoephel J., Reiher W., Rexer K.-H., Kahnt J., Wegener C.;
RT   "Peptidomics of the agriculturally damaging larval stage of the cabbage
RT   root fly Delia radicum (Diptera: Anthomyiidae).";
RL   PLoS ONE 7:E41543-E41543(2012).
CC   -!- FUNCTION: Myotropic peptide. {ECO:0000250|UniProtKB:P41493}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P41493}.
CC   -!- TISSUE SPECIFICITY: In larvae, both sulfakinin and sulfakinin(6-14) are
CC       expressed in the CNS but not the ring gland, thoracic perisympathetic
CC       organs (tPSO) and abdominal perisympathetic organs (aPSO) (at protein
CC       level). In adults, both sulfakinin and sulfakinin(6-14) are expressed
CC       in the brain and thoracic-abdominal ganglion but not in corpora
CC       cardiaca and corpora allata (at protein level).
CC       {ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525}.
CC   -!- DEVELOPMENTAL STAGE: Detected in larvae and adults.
CC       {ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525}.
CC   -!- MASS SPECTROMETRY: [Sulfakinin]: Mass=1686.7; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- MASS SPECTROMETRY: [Sulfakinin]: Mass=1686.68; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- MASS SPECTROMETRY: [Sulfakinin(6-14)]: Mass=1186.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- MASS SPECTROMETRY: [Sulfakinin(6-14)]: Mass=1186.52; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   InterPro; IPR013259; Sulfakinin.
DR   Pfam; PF08257; Sulfakinin; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Sulfakinin"
FT                   /evidence="ECO:0000269|PubMed:20869420,
FT                   ECO:0000269|PubMed:22848525"
FT                   /id="PRO_0000419735"
FT   PEPTIDE         6..14
FT                   /note="Sulfakinin(6-14)"
FT                   /evidence="ECO:0000269|PubMed:20869420,
FT                   ECO:0000269|PubMed:22848525"
FT                   /id="PRO_0000419736"
FT   MOD_RES         14
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:20869420,
FT                   ECO:0000269|PubMed:22848525"
SQ   SEQUENCE   14 AA;  1688 MW;  8B4E06D5AEA7C1AA CRC64;
     GGEEQFDDYG HMRF