ID   SK1_RHYMA               Reviewed;          11 AA.
AC   P04428; P85771;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   11-DEC-2019, entry version 62.
DE   RecName: Full=Sulfakinin-1;
DE            Short=RhyMa-SK-1;
DE   AltName: Full=Leucosulfakinin-1;
DE   AltName: Full=Leucosulfakinin-I;
DE            Short=LSK-I;
OS   Rhyparobia maderae (Madeira cockroach) (Leucophaea maderae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Blaberidae;
OC   Oxyhaloinae; Rhyparobia.
OX   NCBI_TaxID=36963;
RN   [1]
RP   PROTEIN SEQUENCE, SULFATION AT TYR-6, AND AMIDATION AT PHE-11.
RX   PubMed=3749893; DOI=10.1126/science.3749893;
RA   Nachman R.J., Holman G.M., Haddon W.F., Ling N.;
RT   "Leucosulfakinin, a sulfated insect neuropeptide with homology to gastrin
RT   and cholecystokinin.";
RL   Science 234:71-73(1986).
RN   [2]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PHE-11.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=19257902; DOI=10.1186/1471-2148-9-50;
RA   Roth S., Fromm B., Gaede G., Predel R.;
RT   "A proteomic approach for studying insect phylogeny: CAPA peptides of
RT   ancient insect taxa (Dictyoptera, Blattoptera) as a test case.";
RL   BMC Evol. Biol. 9:50-50(2009).
CC   -!- FUNCTION: Changes the frequency and amplitude of contractions of the
CC       hingut. Inhibits muscle contraction of hindgut.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   PIR; A01622; GMROL.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   InterPro; IPR013259; Sulfakinin.
DR   Pfam; PF08257; Sulfakinin; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide; Secreted;
KW   Sulfation.
FT   PEPTIDE         1..11
FT                   /note="Sulfakinin-1"
FT                   /id="PRO_0000043891"
FT   MOD_RES         6
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:3749893"
FT   MOD_RES         11
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:19257902,
FT                   ECO:0000269|PubMed:3749893"
SQ   SEQUENCE   11 AA;  1459 MW;  7E4E0680E86B5AAB CRC64;
     EQFEDYGHMR F