ID   SK2_RHOPR               Reviewed;          14 AA.
AC   P85811;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   11-DEC-2019, entry version 17.
DE   RecName: Full=Sulfakinin-2 {ECO:0000303|PubMed:19137558};
DE            Short=Rhopr-SK-2 {ECO:0000303|PubMed:19137558};
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, OXIDATION AT MET-12, AND AMIDATION AT
RP   PHE-14.
RC   TISSUE=Brain {ECO:0000269|PubMed:19137558};
RX   PubMed=19137558; DOI=10.1002/pmic.200800499;
RA   Ons S., Richter F., Urlaub H., Pomar R.R.;
RT   "The neuropeptidome of Rhodnius prolixus brain.";
RL   Proteomics 9:788-792(2009).
CC   -!- FUNCTION: Myotropic peptide. {ECO:0000250|UniProtKB:P41493}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- PTM: Occurs in two forms, Rhopr-SK-2 contains unmodified Met-12 and Ox-
CC       Rhopr-SK-2 has oxidation at Met-12. {ECO:0000269|PubMed:19137558}.
CC   -!- PTM: Does not contain sulfotyrosine. {ECO:0000269|PubMed:19137558}.
CC   -!- MASS SPECTROMETRY: Mass=1785.75; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:19137558};
CC   -!- MASS SPECTROMETRY: Mass=1801.76; Method=MALDI; Note=With oxidation at
CC       Met-12.; Evidence={ECO:0000269|PubMed:19137558};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000255}.
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DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Oxidation;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Sulfakinin-2"
FT                   /evidence="ECO:0000269|PubMed:19137558"
FT                   /id="PRO_0000365779"
FT   MOD_RES         12
FT                   /note="Methionine sulfoxide"
FT                   /evidence="ECO:0000269|PubMed:19137558"
FT   MOD_RES         14
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:19137558"
SQ   SEQUENCE   14 AA;  1787 MW;  8B4E06CE4AE8ACAA CRC64;
     NSDEQFDDYG YMRF