ID   SKA1_CAEBR              Reviewed;         239 AA.
AC   A8WS92;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Spindle and kinetochore-associated protein 1 homolog;
GN   Name=ska-1 {ECO:0000312|WormBase:CBG02218};
GN   ORFNames=CBG02218 {ECO:0000312|WormBase:CBG02218};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the ska-1 complex, a microtubule-binding
CC       subcomplex of the outer kinetochore that is essential for proper
CC       chromosome segregation. Required for timely anaphase onset during
CC       mitosis, when chromosomes undergo bipolar attachment on spindle
CC       microtubules leading to silencing of the spindle checkpoint. The ska-1
CC       complex is a direct component of the kinetochore-microtubule interface
CC       and directly associates with microtubules as oligomeric assemblies. The
CC       complex facilitates the processive movement of microspheres along a
CC       microtubule in a depolymerization-coupled manner. Affinity for
CC       microtubules is synergistically enhanced in the presence of the ndc-80
CC       complex and may allow the ndc-80 complex to track depolymerizing
CC       microtubules. In the complex, it mediates the interaction with
CC       microtubules. {ECO:0000250|UniProtKB:Q9XWS0}.
CC   -!- SUBUNIT: Component of the ska1 complex, composed of two copies of ska-1
CC       and a single copy of ska-3. The core complex associates with
CC       microtubules and may form dimeric assemblies. Interacts with ska-3 and
CC       microtubules. {ECO:0000250|UniProtKB:Q9XWS0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q9XWS0}. Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q9XWS0}.
CC   -!- SIMILARITY: Belongs to the SKA1 family. {ECO:0000305}.
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DR   EMBL; HE601486; CAP23350.1; -; Genomic_DNA.
DR   RefSeq; XP_002639772.1; XM_002639726.1.
DR   AlphaFoldDB; A8WS92; -.
DR   SMR; A8WS92; -.
DR   STRING; 6238.CBG02218; -.
DR   EnsemblMetazoa; CBG02218.1; CBG02218.1; WBGene00025304.
DR   GeneID; 8581766; -.
DR   KEGG; cbr:CBG_02218; -.
DR   CTD; 8581766; -.
DR   WormBase; CBG02218; CBP14380; WBGene00025304; Cbr-ska-1.
DR   eggNOG; KOG4832; Eukaryota.
DR   HOGENOM; CLU_1143437_0_0_1; -.
DR   InParanoid; A8WS92; -.
DR   OMA; NWRELEI; -.
DR   OrthoDB; 1435835at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0000940; C:outer kinetochore; IBA:GO_Central.
DR   GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IBA:GO_Central.
DR   Gene3D; 1.10.10.1890; -; 1.
DR   InterPro; IPR009829; SKA1.
DR   InterPro; IPR042031; SKA1-MBD.
DR   PANTHER; PTHR28573; PTHR28573; 1.
DR   Pfam; PF07160; SKA1; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW   Kinetochore; Microtubule; Mitosis; Reference proteome.
FT   CHAIN           1..239
FT                   /note="Spindle and kinetochore-associated protein 1
FT                   homolog"
FT                   /id="PRO_0000373889"
FT   REGION          87..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..239
FT                   /note="Microtubule binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q96BD8"
SQ   SEQUENCE   239 AA;  27543 MW;  B481683C6A44EBB7 CRC64;
     MEAFMVSFER QKDAKFCMYR ENIPNFESTL SSITKSTNSI KILLEDISNV QKVITDPCEQ
     SCSSCSPNVL NKFLGIEEKL VNNVEIPDSV PQKSTRPCLD DEKEGSSVVQ PPESGNRHVQ
     LISEQEFKSI PKYQLGRLTL DNLNEIVGKM DEFLTKKNAI LGKTNKQITR QDREVLDNWR
     ELEIKAKGRL PTTLFFIEND IRPLLTERLR LSFAKAIPCL RHIRRVREER CGPLTFYYA