ID   SKA2A_XENLA             Reviewed;         330 AA.
AC   Q5XGP7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Src kinase-associated phosphoprotein 2-A;
GN   Name=skap2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in B-cell and macrophage adhesion processes.
CC       May play a role in src signaling pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated on tyrosines. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKAP family. {ECO:0000305}.
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DR   EMBL; BC084386; AAH84386.1; -; mRNA.
DR   RefSeq; NP_001088334.1; NM_001094865.2.
DR   AlphaFoldDB; Q5XGP7; -.
DR   SMR; Q5XGP7; -.
DR   GeneID; 495172; -.
DR   KEGG; xla:495172; -.
DR   CTD; 495172; -.
DR   Xenbase; XB-GENE-866147; skap2.S.
DR   OMA; KQGFPQD; -.
DR   OrthoDB; 767446at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 495172; Expressed in spleen and 15 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR037781; SKAP_fam.
DR   PANTHER; PTHR15129; PTHR15129; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   B-cell activation; Cytoplasm; Phosphoprotein; Reference proteome;
KW   SH3 domain.
FT   CHAIN           1..330
FT                   /note="Src kinase-associated phosphoprotein 2-A"
FT                   /id="PRO_0000270185"
FT   DOMAIN          105..208
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          268..329
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          53..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  38048 MW;  406BDE42A18A2E2B CRC64;
     MNPALPEDVK NLLTDLETFI LDVLKGETLS KKAKEKKEVL IKRLKDIKHS YPQDFQDKAE
     TDDQEENDGF SLPPDAVSIA SDRDKDEELP YDGSFYPSVA AQDLDYLRAG YLEKRRKDHS
     FFASEWQKRW CVLTNSMFYY YGSDKDKQQK GAFSLDGYRA KMNDTLRKDA KKDCCFEILA
     PDKRVYQFAA SSPKEAEEWI NVIMNARGNI PSEDEELYDD VNQEMDASHE EDIYEELPEE
     SEKPVTGSET PKATPVPVNN TSGKENTDYA NFYRGLWDCN GDHPDELSFK YGDTIYILSK
     EYNTYGWWVG EMKGTIGLVP KAYIIEMYDI