ID   SKA2B_XENLA             Reviewed;         330 AA.
AC   Q5U597;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Src kinase-associated phosphoprotein 2-B;
GN   Name=skap2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in B-cell and macrophage adhesion processes.
CC       May play a role in src signaling pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated on tyrosines. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKAP family. {ECO:0000305}.
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DR   EMBL; BC084787; AAH84787.1; -; mRNA.
DR   RefSeq; NP_001088461.1; NM_001094992.1.
DR   AlphaFoldDB; Q5U597; -.
DR   SMR; Q5U597; -.
DR   DNASU; 495326; -.
DR   GeneID; 495326; -.
DR   KEGG; xla:495326; -.
DR   CTD; 495326; -.
DR   Xenbase; XB-GENE-6253971; skap2.L.
DR   OrthoDB; 767446at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 495326; Expressed in lung and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR037781; SKAP_fam.
DR   PANTHER; PTHR15129; PTHR15129; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   B-cell activation; Cytoplasm; Phosphoprotein; Reference proteome;
KW   SH3 domain.
FT   CHAIN           1..330
FT                   /note="Src kinase-associated phosphoprotein 2-B"
FT                   /id="PRO_0000270186"
FT   DOMAIN          105..208
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          268..329
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          57..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  38147 MW;  024B1AAB33F0D3CA CRC64;
     MNSALPEDVK NLLTELETFL LDVLKAETLS KKGKEKKEIL IKRLKDIKHS YPQEFQDKAE
     DDDQEENDGF PLPPDAVSLA SDRDKDEDLP YDGSFYPPVA AQDLEYLKAG YLEKRRKDHS
     FFASEWQKRW CVFTNSLFYY YGSDKDKQQK GAFSLDGYRA KMNDTLRKDA KKDCCFEIFA
     PDKRVYQFAA SSPKEAEEWI NAIMNSRGII ATEDEELYDD VNQEIDASLE EDIYEELPEE
     SEKPVTETET QKATPVPVNN TSGKENTDYA NFYRGLWDCT GDHPDELSFK HGDTIYIISK
     EYNTYGWWVG EMKGTIGLVP KAYIIEMYDI