位置:首页 > 蛋白库 > SKA2_DANRE
SKA2_DANRE
ID   SKA2_DANRE              Reviewed;         226 AA.
AC   Q0P426;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Spindle and kinetochore-associated protein 2;
DE   AltName: Full=Protein FAM33A;
GN   Name=ska2; Synonyms=fam33a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SKA1 complex, a microtubule-binding
CC       subcomplex of the outer kinetochore that is essential for proper
CC       chromosome segregation. Required for timely anaphase onset during
CC       mitosis, when chromosomes undergo bipolar attachment on spindle
CC       microtubules leading to silencing of the spindle checkpoint. The SKA1
CC       complex is a direct component of the kinetochore-microtubule interface
CC       and directly associates with microtubules as oligomeric assemblies. The
CC       complex facilitates the processive movement of microspheres along a
CC       microtubule in a depolymerization-coupled manner. In the complex, it is
CC       required for ska1 localization. Affinity for microtubules is
CC       synergistically enhanced in the presence of the ndc-80 complex and may
CC       allow the ndc-80 complex to track depolymerizing microtubules.
CC       {ECO:0000250|UniProtKB:Q8WVK7}.
CC   -!- SUBUNIT: Component of the SKA1 complex, composed of ska1, ska2 and
CC       ska3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q8WVK7}. Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q8WVK7}. Note=Localizes to the outer kinetochore
CC       and spindle microtubules during mitosis in a NDC80 complex-dependent
CC       manner. Localizes to both the mitotic spindle and kinetochore-
CC       associated proteins. {ECO:0000250|UniProtKB:Q8WVK7}.
CC   -!- SIMILARITY: Belongs to the SKA2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI22317.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC122316; AAI22317.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q0P426; -.
DR   SMR; Q0P426; -.
DR   STRING; 7955.ENSDARP00000010089; -.
DR   PaxDb; Q0P426; -.
DR   PRIDE; Q0P426; -.
DR   ZFIN; ZDB-GENE-041008-202; ska2.
DR   eggNOG; ENOG502S6SM; Eukaryota.
DR   InParanoid; Q0P426; -.
DR   PhylomeDB; Q0P426; -.
DR   Reactome; R-DRE-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-DRE-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-DRE-9648025; EML4 and NUDC in mitotic spindle formation.
DR   PRO; PR:Q0P426; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000940; C:outer kinetochore; ISS:UniProtKB.
DR   GO; GO:0005876; C:spindle microtubule; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; ISS:UniProtKB.
DR   GO; GO:0007059; P:chromosome segregation; ISS:UniProtKB.
DR   GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; ISS:UniProtKB.
DR   InterPro; IPR026762; Ska2.
DR   InterPro; IPR042091; Ska2_N.
DR   PANTHER; PTHR32017; PTHR32017; 1.
DR   Pfam; PF16740; SKA2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW   Kinetochore; Microtubule; Mitosis; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Spindle and kinetochore-associated protein 2"
FT                   /id="PRO_0000373895"
SQ   SEQUENCE   226 AA;  25296 MW;  66B363FA78B27568 CRC64;
     METVDKLEAM FQKAEADIEY VEKRLKFDFM ASAREAGTFE GNPVELLEDL SAIKARHAAL
     CAQVEEIAAE QKRSMDSIRA HLDTTVQLVQ QLQNTADVQV PPLTEEEQEA RDALCSSVAA
     LNVEAMPTSE PQSQAQSEAQ NVHEDVSEKT FETVPRSVRG NLKLKDLNAL YKQLFEHFSD
     KSRGPISTQR MKKLNMKVND SALKTLQHLK LIELDKKGLV SLLAND
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024