BHD1_SCHPO
ID BHD1_SCHPO Reviewed; 367 AA.
AC O74769;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Folliculin-like protein bhd1;
GN Name=bhd1; ORFNames=SPBC24C6.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the folliculin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAA21152.1; -; Genomic_DNA.
DR PIR; T39972; T39972.
DR RefSeq; NP_595962.1; NM_001021871.2.
DR AlphaFoldDB; O74769; -.
DR SMR; O74769; -.
DR BioGRID; 276828; 20.
DR STRING; 4896.SPBC24C6.08c.1; -.
DR iPTMnet; O74769; -.
DR MaxQB; O74769; -.
DR PaxDb; O74769; -.
DR PRIDE; O74769; -.
DR EnsemblFungi; SPBC24C6.08c.1; SPBC24C6.08c.1:pep; SPBC24C6.08c.
DR GeneID; 2540297; -.
DR KEGG; spo:SPBC24C6.08c; -.
DR PomBase; SPBC24C6.08c; bhd1.
DR VEuPathDB; FungiDB:SPBC24C6.08c; -.
DR eggNOG; KOG3715; Eukaryota.
DR HOGENOM; CLU_035854_0_1_1; -.
DR InParanoid; O74769; -.
DR OMA; THFCDKH; -.
DR PhylomeDB; O74769; -.
DR PRO; PR:O74769; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:1990877; C:FNIP-folliculin RagC/D GAP; EXP:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005774; C:vacuolar membrane; EXP:PomBase.
DR GO; GO:0030120; C:vesicle coat; ISO:PomBase.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; ISO:PomBase.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; EXP:PomBase.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; EXP:PomBase.
DR InterPro; IPR037521; FLCN/SMCR8_DENN.
DR InterPro; IPR021713; Folliculin.
DR InterPro; IPR037520; Folliculin/SMCR8_longin.
DR PANTHER; PTHR31441; PTHR31441; 1.
DR Pfam; PF11704; Folliculin; 1.
DR PROSITE; PS51834; DENN_FLCN_SMCR8; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..367
FT /note="Folliculin-like protein bhd1"
FT /id="PRO_0000223944"
FT DOMAIN 131..302
FT /note="uDENN FLCN/SMCR8-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01178"
FT REGION 41..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 40799 MW; 2FA7D7321671158A CRC64;
MDVVFALGHF CEAEGPSIIF CTQKLHRSTV SKFFEHPTSK RSIGVTENGN DSPEAFKNEL
DNRNNADSQS LQSSTESLFK ADSEDYLCKK VSKGPESPRV NSFHNSYSRN QSPISRKSSC
VTCSTVLPLE FSVPDVQPRL YTNSSTNPDV LYMSSQHPHT QQRYSTLKRL MVRCLSCEYS
TLSEASDSMS NPLFFGDQDN GYVISQSFSL RDPSARGGLR RYAIIATCPN QLDLILRYSF
ISEKFLHIVQ FLRISSFNTK NDYSSSRSKT TASSSNGTFA SPSFNISSLS GSSNIGTAPS
YEISSSIGAN VSSLAHTQRL PSFSFLRRRD DIGEGRSLVD ITCWDGIFVG LHSSFSWILE
VWDLLVV
