ID   BHE22_CHICK             Reviewed;         311 AA.
AC   Q71T09;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Class E basic helix-loop-helix protein 22;
DE            Short=bHLHe22;
DE   AltName: Full=Class B basic helix-loop-helix protein 5;
DE            Short=bHLHb5;
DE   AltName: Full=NeuroB;
DE   AltName: Full=Protein BETA3;
GN   Name=BHLHE22; Synonyms=BHLHB5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Minabe-Saegusa C., Takahashi M., Ujita M., Yuasa J., Noda M.;
RT   "NeuroB, a novel basic helix-loop-helix protein can act as a
RT   transcriptional repressor of GAP-43 during retinogenesis in chick.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AF247676; AAQ14265.1; -; mRNA.
DR   RefSeq; NP_989834.1; NM_204503.1.
DR   AlphaFoldDB; Q71T09; -.
DR   SMR; Q71T09; -.
DR   GeneID; 395164; -.
DR   KEGG; gga:395164; -.
DR   CTD; 27319; -.
DR   VEuPathDB; HostDB:geneid_395164; -.
DR   InParanoid; Q71T09; -.
DR   OrthoDB; 1617813at2759; -.
DR   PhylomeDB; Q71T09; -.
DR   PRO; PR:Q71T09; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR032654; Bhlhe22.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   PANTHER; PTHR19290:SF52; PTHR19290:SF52; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..311
FT                   /note="Class E basic helix-loop-helix protein 22"
FT                   /id="PRO_0000274287"
FT   DOMAIN          171..225
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          22..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   311 AA;  31543 MW;  009931DE1C84756B CRC64;
     MERALGLPAE EDLFHKSLAA SAKRMESAFR SPPGLDLSHP RDRQPSPLAC YEAPEPEALL
     QPGVGGDPLA LPPGSVCVKY GESASRSSVA ESSGGEQSPD DDSDGRCELL LRGAGGDPRD
     ASPAAGGGGG GGGGGGGGPG GGGGGGLKAA EGGCSNGHGH GGSKKSKEQK ALRLNINARE
     RRRMHDLNDA LDELRAVIPY AHSPSVRKLS KIATLLLAKN YILMQAQALE EMRRLVAYLN
     QGQAISAASL PSSAAAAAAA AAALHPALGA YEQAAGYPFS AGLPPATSCP EKCAIFNSVS
     SSLCKQCTEK P