ID   SKAP1_TAKRU             Reviewed;         363 AA.
AC   Q1KKW7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Src kinase-associated phosphoprotein 1;
DE   AltName: Full=Src family-associated phosphoprotein 1;
GN   Name=skap1; Synonyms=scap1;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Positively regulates T-cell receptor signaling. Required for
CC       optimal conjugation between T-cells and antigen-presenting cells (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cell membrane {ECO:0000250}. Note=Upon T-cell stimulation, translocates
CC       to lipid rafts at the cell membrane. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on tyrosines. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKAP family. {ECO:0000305}.
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DR   EMBL; DQ481666; ABF22427.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1KKW7; -.
DR   SMR; Q1KKW7; -.
DR   STRING; 31033.ENSTRUP00000030563; -.
DR   eggNOG; ENOG502QSSU; Eukaryota.
DR   HOGENOM; CLU_062032_0_0_1; -.
DR   InParanoid; Q1KKW7; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   CDD; cd12044; SH3_SKAP1; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035765; SKAP1_SH3.
DR   InterPro; IPR037781; SKAP_fam.
DR   PANTHER; PTHR15129; PTHR15129; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity; Cell membrane; Cytoplasm; Immunity; Membrane; Nucleus;
KW   Phosphoprotein; Reference proteome; SH3 domain.
FT   CHAIN           1..363
FT                   /note="Src kinase-associated phosphoprotein 1"
FT                   /id="PRO_0000270176"
FT   DOMAIN          118..221
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          301..362
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          62..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..247
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  41279 MW;  4BFE711B49E12301 CRC64;
     MEAVDLLANV SVTGLLLFWG DCEFFVSEIL YDENLSENAQ ETRKVLLNNF RVVHVRNPQE
     FPFPSDYKEE DGSDDNRSSS LGRSAQSDDA SLASDNQDDG IPEYFGDIPP VAAQDIVNVL
     KQGYLEKKRK DHSFFGSEWQ KRWCVLNNLV FYYFGSDKDK QQKGSFYISD YSVQLVTNLR
     KDSRKTSCFE FFAPGRRPFQ FTAGSPQEAK EWVDQIKIVL RDLSSTVIPV DDEEEEEEEE
     ETYDDIEGEG GPPLPQPLSG TWGRGGDTGA ADEEDEDIYE VLPEESPDSA DGSMERNNKP
     EYANYYQGLW DCSADEPDEL PFQRGDLIYI ISKEYNIYGW WVGELNGAVG IVPKDFLHPA
     YIL