ID   SKAP2_DANRE             Reviewed;         341 AA.
AC   Q6PG29;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Src kinase-associated phosphoprotein 2;
DE   AltName: Full=Src family-associated phosphoprotein 2;
GN   Name=skap2; Synonyms=scap2; ORFNames=zgc:65975;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in B-cell and macrophage adhesion processes.
CC       May play a role in src signaling pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated on tyrosines. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKAP family. {ECO:0000305}.
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DR   EMBL; BC057253; AAH57253.1; -; mRNA.
DR   RefSeq; NP_956922.1; NM_200628.1.
DR   AlphaFoldDB; Q6PG29; -.
DR   SMR; Q6PG29; -.
DR   STRING; 7955.ENSDARP00000052659; -.
DR   PaxDb; Q6PG29; -.
DR   Ensembl; ENSDART00000052660; ENSDARP00000052659; ENSDARG00000000906.
DR   GeneID; 368564; -.
DR   KEGG; dre:368564; -.
DR   CTD; 8935; -.
DR   ZFIN; ZDB-GENE-030616-438; skap2.
DR   eggNOG; ENOG502QVFD; Eukaryota.
DR   GeneTree; ENSGT00390000017856; -.
DR   HOGENOM; CLU_062032_0_0_1; -.
DR   InParanoid; Q6PG29; -.
DR   OMA; KQGFPQD; -.
DR   OrthoDB; 767446at2759; -.
DR   PhylomeDB; Q6PG29; -.
DR   TreeFam; TF331055; -.
DR   PRO; PR:Q6PG29; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000000906; Expressed in granulocyte and 20 other tissues.
DR   ExpressionAtlas; Q6PG29; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR037781; SKAP_fam.
DR   PANTHER; PTHR15129; PTHR15129; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   B-cell activation; Cytoplasm; Phosphoprotein; Reference proteome;
KW   SH3 domain.
FT   CHAIN           1..341
FT                   /note="Src kinase-associated phosphoprotein 2"
FT                   /id="PRO_0000270183"
FT   DOMAIN          105..208
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          279..340
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          54..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..89
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  39185 MW;  499C352D1D45675B CRC64;
     MRSVPEDFTT LISDLETFLT DVLKGENLSK KAKEKKDAFI KRIKDVKTSY AQEFKDRRDE
     EFPEPDEADT NDGGSLHSEQ TDRDDENAYD GVQQSPPVAA QDLQAVLKSG YLEKRRKDHS
     FFGNEWQKRW CALNNSIFYY YGSEKDKQQK GEFNIVGYTV KMNNTLRKDA KRDCCFEVSA
     PDKRVYQFCA ASEKEAKEWV EHIDFLIKDL GGIIPEDEEE YDDCLSMSQS EVAILPDDDI
     YEELPEEDVP QPSKPKVTLV NKPPPPATPV TAAVNKSTDY ANYFQGLWDC IGDQPDELSF
     KRGDTIYILS KEYDMFGWWV GEMKGVIGIV PKEYLLELYV L