ID   SKAP2_XENTR             Reviewed;         328 AA.
AC   Q5FVW6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Src kinase-associated phosphoprotein 2;
GN   Name=skap2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in B-cell and macrophage adhesion processes.
CC       May play a role in src signaling pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated on tyrosines. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKAP family. {ECO:0000305}.
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DR   EMBL; BC089739; AAH89739.1; -; mRNA.
DR   AlphaFoldDB; Q5FVW6; -.
DR   SMR; Q5FVW6; -.
DR   STRING; 8364.ENSXETP00000026585; -.
DR   PaxDb; Q5FVW6; -.
DR   Ensembl; ENSXETT00000007588; ENSXETP00000007588; ENSXETG00000012181.
DR   eggNOG; ENOG502QVFD; Eukaryota.
DR   HOGENOM; CLU_062032_0_0_1; -.
DR   InParanoid; Q5FVW6; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012181; Expressed in liver and 7 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR037781; SKAP_fam.
DR   PANTHER; PTHR15129; PTHR15129; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   B-cell activation; Cytoplasm; Phosphoprotein; Reference proteome;
KW   SH3 domain.
FT   CHAIN           1..328
FT                   /note="Src kinase-associated phosphoprotein 2"
FT                   /id="PRO_0000270187"
FT   DOMAIN          103..206
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          266..327
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          231..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   328 AA;  37863 MW;  4F17518D69BE3F47 CRC64;
     MNPALPEDVK TLLTDLETFI SDVLKGETLS KKAKEKKEVL IKRLKDIKHS HSLEFQAETD
     DLEENDGFPL PPDAVSIASD RDKDEELPYD GSFYPLVAAQ DLEYLRAGYL EKRRKDHSFF
     ASEWQKRWCV CTNSMFYYYG SDKDKQQKGA FSLDGYRAKM NDTLRKDAKK DCCFEIFAPD
     KRVYQFAASS PKEAEEWVNI IMNSRGNIPT EDEELYDDVN QEVDASHEED IYEELPEESE
     KPVTEIETPK ATPVPVNNTS GKENTDYANF YRGLWDCTGD HPDELSFKHG DTIYILSKEY
     NTYGWWVGEM KGTIGLVPKA YIMEMYDI