SKAT1_CAEEL
ID SKAT1_CAEEL Reviewed; 460 AA.
AC P34479; Q9U3E0;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Probable amino acid transporter skat-1 {ECO:0000303|PubMed:24204312};
DE AltName: Full=Protein suppressor of kat-1 {ECO:0000312|WormBase:F59B2.2};
GN Name=skat-1 {ECO:0000312|WormBase:F59B2.2};
GN ORFNames=F59B2.2 {ECO:0000312|WormBase:F59B2.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=24204312; DOI=10.1371/journal.pgen.1003908;
RA Soukas A.A., Carr C.E., Ruvkun G.;
RT "Genetic regulation of Caenorhabditis elegans lysosome related organelle
RT function.";
RL PLoS Genet. 9:E1003908-E1003908(2013).
CC -!- FUNCTION: Plays a role in the accumulation of vital dyes and endogenous
CC fluorescent compounds in lysosome related organelles. Has an effect on
CC lysosome related organelle (LRO) function, in a pathway with serotonin.
CC {ECO:0000269|PubMed:24204312}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}. Cytoplasmic granule
CC {ECO:0000269|PubMed:24204312}.
CC -!- TISSUE SPECIFICITY: Expressed in the head, tail, body and ventral nerve
CC cord neurons, muscles of the vulva, and intestine.
CC {ECO:0000269|PubMed:24204312}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; Z11505; CAA77582.1; -; Genomic_DNA.
DR PIR; F88544; F88544.
DR PIR; S31123; S31123.
DR RefSeq; NP_498989.1; NM_066588.4.
DR AlphaFoldDB; P34479; -.
DR STRING; 6239.F59B2.2; -.
DR TCDB; 2.A.18.8.8; the amino acid/auxin permease (aaap) family.
DR iPTMnet; P34479; -.
DR EPD; P34479; -.
DR PaxDb; P34479; -.
DR PeptideAtlas; P34479; -.
DR EnsemblMetazoa; F59B2.2.1; F59B2.2.1; WBGene00010307.
DR GeneID; 176271; -.
DR KEGG; cel:CELE_F59B2.2; -.
DR UCSC; F59B2.2; c. elegans.
DR CTD; 176271; -.
DR WormBase; F59B2.2; CE20899; WBGene00010307; skat-1.
DR eggNOG; KOG1304; Eukaryota.
DR HOGENOM; CLU_009646_0_1_1; -.
DR InParanoid; P34479; -.
DR OMA; IAMYVVF; -.
DR OrthoDB; 464614at2759; -.
DR PhylomeDB; P34479; -.
DR Reactome; R-CEL-352230; Amino acid transport across the plasma membrane.
DR Reactome; R-CEL-428559; Proton-coupled neutral amino acid transporters.
DR Reactome; R-CEL-71240; Tryptophan catabolism.
DR PRO; PR:P34479; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00010307; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..460
FT /note="Probable amino acid transporter skat-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000093831"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 460 AA; 51338 MW; 0D78809A84EF15BA CRC64;
MSEEEGRERA VTVEGDAESM NDGRALVQPP ARSGDVITPT RAVLTLSKSM FNAGCFSLPY
AWKLGGLWVS FVMSFVIAGL NWYGNHILVR ASQHLAKKSD RSALDYGHFA KKVCDYSDIR
FLRNNSKAVM YFVNVTILFY QLGMCSVAIL FISDNLVNLV GDHLGGTRHQ QMILMATVSL
FFILLTNMFT EMRIVSFFAL VSSVFFVIGA AVIMQYTVQQ PNQWDKLPAA TNFTGTITMI
GMSMYAFEGQ TMILPIENKL DNPAAFLAPF GVLSTTMIIC TAFMTALGFF GYTGFGDSIA
PTITTNVPKE GLYSTVNVFL MLQSLLGNSI AMYVVYDMFF NGFRRKFGAR FPNVPKWLSD
KGFRVFWVLV TYLMAVLIPK LEIMIPLVGV TSGALCALIF PPFFEMITFW TDWKGLLTYR
QRMTKIFINL VVMAIGVFAI IAGVYTNIHA IIQSFSQPDP
