ID   SKB5_SCHPO              Reviewed;         140 AA.
AC   Q9US59;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Shk1 kinase-binding protein 5;
GN   Name=skb5; ORFNames=SPCC24B10.13;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, PHOSPHORYLATION, AND
RP   INTERACTION WITH SHK1.
RX   PubMed=10593886; DOI=10.1074/jbc.274.51.36052;
RA   Yang P., Pimental R.A., Lai H., Marcus S.;
RT   "Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain
RT   protein, Skb5.";
RL   J. Biol. Chem. 274:36052-36057(1999).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Stimulates catalytic function of the p21-activated kinase
CC       homolog shk1. {ECO:0000269|PubMed:10593886}.
CC   -!- SUBUNIT: Interacts with N-terminal regulatory domain of shk1 via SH3
CC       domain. {ECO:0000269|PubMed:10593886}.
CC   -!- PTM: Phosphorylated in vivo. In vitro, phosphorylated by shk1.
CC       {ECO:0000269|PubMed:10593886}.
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DR   EMBL; AF192549; AAF19175.1; -; Genomic_DNA.
DR   EMBL; CU329672; CAB76222.1; -; Genomic_DNA.
DR   PIR; T50420; T50420.
DR   RefSeq; NP_588016.1; NM_001023007.1.
DR   AlphaFoldDB; Q9US59; -.
DR   SMR; Q9US59; -.
DR   BioGRID; 275807; 36.
DR   IntAct; Q9US59; 1.
DR   STRING; 4896.SPCC24B10.13.1; -.
DR   PaxDb; Q9US59; -.
DR   EnsemblFungi; SPCC24B10.13.1; SPCC24B10.13.1:pep; SPCC24B10.13.
DR   GeneID; 2539237; -.
DR   KEGG; spo:SPCC24B10.13; -.
DR   PomBase; SPCC24B10.13; skb5.
DR   VEuPathDB; FungiDB:SPCC24B10.13; -.
DR   eggNOG; ENOG502RZ32; Eukaryota.
DR   HOGENOM; CLU_069841_1_0_1; -.
DR   InParanoid; Q9US59; -.
DR   OMA; YDFEPLH; -.
DR   PhylomeDB; Q9US59; -.
DR   PRO; PR:Q9US59; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0030295; F:protein kinase activator activity; IDA:PomBase.
DR   GO; GO:0019901; F:protein kinase binding; IDA:UniProtKB.
DR   GO; GO:0035556; P:intracellular signal transduction; IPI:PomBase.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF14604; SH3_9; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; SH3 domain.
FT   CHAIN           1..140
FT                   /note="Shk1 kinase-binding protein 5"
FT                   /id="PRO_0000097777"
FT   DOMAIN          80..140
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192,
FT                   ECO:0000305"
SQ   SEQUENCE   140 AA;  15857 MW;  152B7D68DED80A20 CRC64;
     MAEETEEDYL VVGRDYLYPP DHELHYGFHA RVIEEEEERF VDDTFDETIE GSDDSESIDD
     TEVFYDAEES ESTHPSASFN VLADAVALYD FEPLHDNELG FTTGQRLCIL SESSDGWLIA
     YDDASGRSGL VPETFVKLEV