SKDA1_HUMAN
ID SKDA1_HUMAN Reviewed; 908 AA.
AC Q1XH10; B1ANA5; E9PAX1; F5H7M0; Q6ZMX4; Q8N3C3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=SKI/DACH domain-containing protein 1;
DE AltName: Full=Protein DLN-1;
GN Name=SKIDA1; Synonyms=C10orf140, DLN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Neuroblastoma;
RA Takenobu H., Ohira M., Nakamura Y., Hirata T., Nakagawara A.;
RT "Cloning of a full-length human DLN-1 gene.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 346-908.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-688, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=1;
CC IsoId=Q1XH10-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1XH10-2; Sequence=VSP_059383;
CC -!- POLYMORPHISM: The poly-Ala region of SKIDA1 is highly polymorphic and
CC the number of Ala can vary. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DACH/dachshund family. {ECO:0000305}.
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DR EMBL; AB234866; BAE93016.1; -; mRNA.
DR EMBL; AK131456; BAD18601.1; -; mRNA.
DR EMBL; AL358780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL834446; CAD39106.1; -; mRNA.
DR CCDS; CCDS44363.1; -. [Q1XH10-1]
DR RefSeq; NP_997254.3; NM_207371.3. [Q1XH10-1]
DR RefSeq; XP_005252507.1; XM_005252450.3. [Q1XH10-1]
DR RefSeq; XP_011517782.1; XM_011519480.2. [Q1XH10-1]
DR RefSeq; XP_016871714.1; XM_017016225.1. [Q1XH10-1]
DR RefSeq; XP_016871715.1; XM_017016226.1. [Q1XH10-1]
DR AlphaFoldDB; Q1XH10; -.
DR SMR; Q1XH10; -.
DR BioGRID; 132378; 16.
DR IntAct; Q1XH10; 2.
DR STRING; 9606.ENSP00000410041; -.
DR iPTMnet; Q1XH10; -.
DR PhosphoSitePlus; Q1XH10; -.
DR BioMuta; SKIDA1; -.
DR DMDM; 121940921; -.
DR MassIVE; Q1XH10; -.
DR PaxDb; Q1XH10; -.
DR PeptideAtlas; Q1XH10; -.
DR PRIDE; Q1XH10; -.
DR ProteomicsDB; 19097; -.
DR ProteomicsDB; 27525; -.
DR ProteomicsDB; 61253; -.
DR Antibodypedia; 50910; 68 antibodies from 12 providers.
DR DNASU; 387640; -.
DR Ensembl; ENST00000444772.3; ENSP00000442432.1; ENSG00000180592.17. [Q1XH10-2]
DR Ensembl; ENST00000449193.7; ENSP00000410041.2; ENSG00000180592.17. [Q1XH10-1]
DR GeneID; 387640; -.
DR KEGG; hsa:387640; -.
DR MANE-Select; ENST00000449193.7; ENSP00000410041.2; NM_207371.4; NP_997254.3.
DR CTD; 387640; -.
DR GeneCards; SKIDA1; -.
DR HGNC; HGNC:32697; SKIDA1.
DR HPA; ENSG00000180592; Low tissue specificity.
DR neXtProt; NX_Q1XH10; -.
DR OpenTargets; ENSG00000180592; -.
DR PharmGKB; PA162377645; -.
DR VEuPathDB; HostDB:ENSG00000180592; -.
DR eggNOG; KOG3915; Eukaryota.
DR GeneTree; ENSGT00940000153451; -.
DR InParanoid; Q1XH10; -.
DR OMA; QPTFHYN; -.
DR OrthoDB; 759791at2759; -.
DR PhylomeDB; Q1XH10; -.
DR TreeFam; TF332913; -.
DR PathwayCommons; Q1XH10; -.
DR SignaLink; Q1XH10; -.
DR BioGRID-ORCS; 387640; 11 hits in 1074 CRISPR screens.
DR ChiTaRS; SKIDA1; human.
DR GenomeRNAi; 387640; -.
DR Pharos; Q1XH10; Tdark.
DR PRO; PR:Q1XH10; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q1XH10; protein.
DR Bgee; ENSG00000180592; Expressed in endothelial cell and 108 other tissues.
DR Genevisible; E9PAX1; HS.
DR Gene3D; 3.10.260.20; -; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR027971; EPOP.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR Pfam; PF15223; EPOP; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
PE 1: Evidence at protein level;
KW Alternative initiation; Isopeptide bond; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..908
FT /note="SKI/DACH domain-containing protein 1"
FT /id="PRO_0000328529"
FT REGION 337..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..368
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 688
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 240..318
FT /note="Missing (in isoform 2)"
FT /id="VSP_059383"
FT CONFLICT 229..239
FT /note="Missing (in Ref. 2; BAD18601)"
FT /evidence="ECO:0000305"
FT CONFLICT 238..239
FT /note="Missing (in Ref. 1; BAE93016)"
FT /evidence="ECO:0000305"
FT CONFLICT 428
FT /note="E -> EEE (in Ref. 2; BAD18601 and 4; CAD39106)"
FT /evidence="ECO:0000305"
FT CONFLICT 850
FT /note="F -> K (in Ref. 2; BAD18601)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 908 AA; 98148 MW; 6B028EAA32881D2B CRC64;
MGDLKSGFEE VDGVRLGYLI IKGKQMFALS QVFTDLLKNI PRTTVHKRMD HLKVKKHHCD
LEELRKLKAI NSIAFHAAKC TLISREDVEA LYTSCKTERV LKTKRRRVGR ALATKAPPPE
RAAAASPRPG FWKDKHQLWR GLSGAARPLP ISAQSQRPGA AAARPAAHLP QIFSKYPGSH
YPEIVRSPCK PPLNYETAPL QGNYVAFPSD PAYFRSLLCS KHPAAAAAAA AAAAAAAAAA
AAAAYYQVSA AGPQPKAAAG AGGPGSLSYR CKRKRGGAKD CLLAPHAGAR RLLLLPRSYK
AKAAAAAAAA AAAAAAAAGA TCLERFHLVN GFCPPPHHHH HHHHHHHHHH HRAQPPQQSH
HPPHHHRPQP HLGSFPESCS SDSESSSYSD HAANDSDFGS SLSSSSNSVS SEEEEEEGEE
EEEEEEEEGG SGASDSSEVS SEEEDSSTES DSSSGSSQVS VQSIRFRRTS FCKPPSVQAQ
ANFLYHLASA AAATKPAAFE DAGRLPDLKS SVKAESPAEW NLQSWAPKAS PVYCPASLGS
CFAEIRNDRV SEITFPHSEI SNAVKRTDLT INCLAEGASS PSPKTNNAFP QQRILREARK
CLQTTPTTHC ADNNTIAARF LNNDSSGAEA NSEKYSKILH CPEFATDLPS SQTDPEVNAA
GAAATKAENP CTDTGDKTLP FLHNIKIKVE DSSANEEYEP HLFTNKLKCE CNDTKGEFYS
VTESKEEDAL LTTAKEGFAC PEKETPSLNP LAQSQGLSCT LGSPKPEDGE YKFGARVRKN
YRTLVLGKRP VLQTPPVKPN LKSARSPRPT GKTETNEGTL DDFTVINRRK KVASNVASAV
KRPFHFMANF PCPPSLIIGR DGDLWPAYSL NTTKDSQTPH KAHPIWKWQL GGSAIPLPPS
HKFRKFNS
