SKDA1_MOUSE
ID SKDA1_MOUSE Reviewed; 822 AA.
AC Q80YR3; A6PWY1; A6PWY2; Q9CSH2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=SKI/DACH domain-containing protein 1;
DE AltName: Full=Protein DLN-1;
GN Name=Skida1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 692-822.
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SIMILARITY: Belongs to the DACH/dachshund family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAO78132.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAO78133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL928589; CAM21798.1; -; Genomic_DNA.
DR EMBL; AL928589; CAO78132.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL928589; CAO78133.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC050860; AAH50860.1; -; mRNA.
DR EMBL; AK012843; BAB28505.1; -; mRNA.
DR RefSeq; NP_082593.2; NM_028317.2.
DR AlphaFoldDB; Q80YR3; -.
DR SMR; Q80YR3; -.
DR STRING; 10090.ENSMUSP00000088982; -.
DR iPTMnet; Q80YR3; -.
DR PhosphoSitePlus; Q80YR3; -.
DR PaxDb; Q80YR3; -.
DR PRIDE; Q80YR3; -.
DR Antibodypedia; 50910; 68 antibodies from 12 providers.
DR Ensembl; ENSMUST00000066885; ENSMUSP00000068520; ENSMUSG00000054074.
DR GeneID; 72668; -.
DR KEGG; mmu:72668; -.
DR CTD; 387640; -.
DR MGI; MGI:1919918; Skida1.
DR VEuPathDB; HostDB:ENSMUSG00000054074; -.
DR eggNOG; KOG3915; Eukaryota.
DR GeneTree; ENSGT00940000153451; -.
DR HOGENOM; CLU_021969_0_0_1; -.
DR InParanoid; Q80YR3; -.
DR OrthoDB; 759791at2759; -.
DR PhylomeDB; Q80YR3; -.
DR BioGRID-ORCS; 72668; 1 hit in 57 CRISPR screens.
DR ChiTaRS; Skida1; mouse.
DR PRO; PR:Q80YR3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q80YR3; protein.
DR Bgee; ENSMUSG00000054074; Expressed in retinal neural layer and 72 other tissues.
DR ExpressionAtlas; Q80YR3; baseline and differential.
DR Gene3D; 3.10.260.20; -; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR027971; EPOP.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR Pfam; PF15223; EPOP; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Reference proteome; Ubl conjugation.
FT CHAIN 1..822
FT /note="SKI/DACH domain-containing protein 1"
FT /id="PRO_0000328530"
FT REGION 245..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..276
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..358
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 602
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q1XH10"
FT CONFLICT 692
FT /note="R -> K (in Ref. 3; BAB28505)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 822 AA; 90309 MW; EE1ACD579C5ED389 CRC64;
MGDLKSGFEE VDGVRLGYLI IKGKQMFALS QVFTDLLKNI PRTTVHKRMD HLKVKKHHCD
LEELRKLKAI NSIAFHAAKC TLISREDVEA LYTSCKTERV LKTKRRRVGR ALATKAPPPE
RAAAASPRPA FWKDKHQLWR GLSGAARPLP ISAQSQRPGA AAARPAAHLP QIFSKYPGSH
YPEIVRSPCK SSLNYETAQL QGNYVAFHSD PAYFRSLLCS KHPAAAGATC LERFHLVNSF
CPPPHHHHHH HHHHHHHHHR AQQPTPSHHP SHHHRPQPHL GSFPESCSSD SESSSYSDHA
ANDSDFGSSL SSSSNSVSSE EEEEEGEEEE EEEEEEEGGS GASDSSEISS EEEDSSTESD
SSSGSSQVSV QSIRFRRTSF CKPPSVQAQA NFLYHLASAA AATKPAAFED AGRLPDLKSS
VKAESPEEWS LQSWAPKGTP VYCPASLGSC FPEIRNDRVS EITFPHSEIS STVKRTDLTI
NCHAEGASSP SPKTNNVFPQ QRILREARKC LQATPTTHCA ENSTIAARFL NNDSCGTTAN
SGKDSKIPHC PEFATDLPSL QSDPRVDTAT AAAAAAAATK AESLCTGTGD KTLPFLHNIK
IKVEDSSANE EYEPELITNK LKWECNDAEG EFYNMTEKKE EDALVPTAKE GFACPEKETP
SLNPLAQSQG LSCTLGSPKP EDGEYKFGAR VRKNYRTLVL GKRPVLQTPP VKPNLKSARS
PRPTGKTETH EGTLDDFTVL NRRKKVASNV ASAVKRPFNF MANFPCPPSL IIGKDGDLWP
AYSLNTTKDS QPPHKAHPIW KWQLGGSAIP LPPSHKFRKF NS
