ID   SKFG_BACSU              Reviewed;         171 AA.
AC   O31429; Q7DL60;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Uncharacterized protein SkfG;
GN   Name=skfG {ECO:0000303|PubMed:12817086}; Synonyms=ybdD;
GN   OrderedLocusNames=BSU01970;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Haga K., Liu H., Yasumoto K., Takahashi H., Yoshikawa H.;
RT   "Sequence analysis of the 70kb region between 17 and 23 degree of the
RT   Bacillus subtilis chromosome.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 108 AND C-TERMINUS.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   FUNCTION IN SYNTHESIS OF SKFA, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168 / PY79;
RX   PubMed=12817086; DOI=10.1126/science.1086462;
RA   Gonzalez-Pastor J.E., Hobbs E.C., Losick R.;
RT   "Cannibalism by sporulating bacteria.";
RL   Science 301:510-513(2003).
RN   [5]
RP   REPRESSION BY ABRB AND ABH.
RX   PubMed=17720793; DOI=10.1128/jb.01081-07;
RA   Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y.;
RT   "Abh and AbrB control of Bacillus subtilis antimicrobial gene expression.";
RL   J. Bacteriol. 189:7720-7732(2007).
CC   -!- FUNCTION: Required for production of the bacteriocin SkfA.
CC       {ECO:0000269|PubMed:12817086}.
CC   -!- INDUCTION: By Spo0A (PubMed:12817086) and PhoP, during nutrient
CC       starvation, especially phosphate starvation. Repressed by AbrB during
CC       normal growth when nutrients are plentiful, in association with the
CC       transcriptional repressor Abh. {ECO:0000269|PubMed:12817086,
CC       ECO:0000269|PubMed:17720793}.
CC   -!- DISRUPTION PHENOTYPE: When the skfA-skfB-skfC-skfE-skfF-skfG-skfH
CC       operon is deleted, increased rate of spore formation; a double operon
CC       deletion (sdpA-sdpC plus skfA-skfH) makes spores even faster
CC       (PubMed:12817086). {ECO:0000269|PubMed:12817086}.
CC   -!- MISCELLANEOUS: Accelerated cannibalism by skf- cells is seen on solid
CC       media but not in liquid media. {ECO:0000269|PubMed:12817086}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA33094.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB006424; BAA33094.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL009126; CAB11991.2; -; Genomic_DNA.
DR   PIR; B69747; B69747.
DR   RefSeq; NP_388079.2; NC_000964.3.
DR   RefSeq; WP_003234897.1; NZ_JNCM01000030.1.
DR   AlphaFoldDB; O31429; -.
DR   SMR; O31429; -.
DR   STRING; 224308.BSU01970; -.
DR   PaxDb; O31429; -.
DR   PRIDE; O31429; -.
DR   EnsemblBacteria; CAB11991; CAB11991; BSU_01970.
DR   GeneID; 938502; -.
DR   KEGG; bsu:BSU01970; -.
DR   PATRIC; fig|224308.179.peg.203; -.
DR   eggNOG; COG1413; Bacteria.
DR   OMA; CIAWIDP; -.
DR   BioCyc; BSUB:BSU01970-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0030152; P:bacteriocin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Antibiotic biosynthesis; Bacteriocin biosynthesis; Reference proteome.
FT   CHAIN           1..171
FT                   /note="Uncharacterized protein SkfG"
FT                   /id="PRO_0000312742"
FT   CONFLICT        108
FT                   /note="Q -> H (in Ref. 1; BAA33094)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   171 AA;  18510 MW;  2C785B00DE483C19 CRC64;
     MNSNGDKLSL SVQNLANTNE ITIVQAIGEL KKSGKDAIPV LVEALKEEGS LCNIAAAVLG
     EFGEDASEAA EELSCLLKSH AEDTRMAAAI SLMRIGKPSL PFVIKIAQES EGQSCFWASW
     CIAWIDPSCI EPKMYKCLKY EHEHPSGIVA PFAAEEALGK LIAFQLKDKE D