ID   SKG1_CANGA              Reviewed;         360 AA.
AC   Q6FLL2;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Suppressor of lethality of KEX2 GAS1 double null mutant protein 1;
GN   Name=SKG1; OrderedLocusNames=CAGL0L02563g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Plays a role in cell wall integrity. Affects the cell wall
CC       polymer composition in the growing region of the cell (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Bud
CC       membrane {ECO:0000250}; Single-pass type III membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localizes on the
CC       inner surface of the plasma membrane at the bud and in the daughter
CC       cell. Localizes at an incipient bud site in the cells with emerging
CC       buds, a bud tip in small- or medium-budded cells, and a cell periphery
CC       in large-budded cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKG1 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG61852.1; -; Genomic_DNA.
DR   RefSeq; XP_448882.1; XM_448882.1.
DR   AlphaFoldDB; Q6FLL2; -.
DR   STRING; 5478.XP_448882.1; -.
DR   EnsemblFungi; CAG61852; CAG61852; CAGL0L02563g.
DR   GeneID; 2890857; -.
DR   KEGG; cgr:CAGL0L02563g; -.
DR   CGD; CAL0135652; CAGL0L02563g.
DR   VEuPathDB; FungiDB:CAGL0L02563g; -.
DR   eggNOG; ENOG502RZI6; Eukaryota.
DR   HOGENOM; CLU_079389_0_0_1; -.
DR   InParanoid; Q6FLL2; -.
DR   OMA; KYYVPAY; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0033101; C:cellular bud membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell membrane; Cell wall biogenesis/degradation; Membrane;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..360
FT                   /note="Suppressor of lethality of KEX2 GAS1 double null
FT                   mutant protein 1"
FT                   /id="PRO_0000399669"
FT   TOPO_DOM        1..8
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..360
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          63..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  40439 MW;  6175CD45E64E0C89 CRC64;
     MTGTVSTAVG CAVGIPVGVG VIVACLFWIR MQRRLKEEDI IDQELNRAVY DESGFVSFNN
     IDTLKAEPNG HPSSEDTNEV MHSSDIDDNG DDDDEDHNAR RNNTYAAQDK NNGKYVPAYR
     RQINKHNSIL QQQRKSRNLV NTMGHSIESL SMDDHSQANG KSRQVSVYDQ MVPVLDDANR
     DSSSPFPTND KDTSDKKSNL FQSHDVSANT STSFFETRSN DNLIKNLNSH DFGSYYPRRP
     STSNLNHSQG SLHTRNSSML SLGKIENAEN VFATPKSENI LKHPHPLEHE SSSISNETNN
     VTDNTIDGES ASKSSKTYQL KNNYDIQNTS EIAEEDQYEN EFTNYSENKR AYIDGLRPKM