ID   SKG1_LACTC              Reviewed;         314 AA.
AC   C5DH21;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Suppressor of lethality of KEX2 GAS1 double null mutant protein 1;
GN   Name=SKG1; OrderedLocusNames=KLTH0E00726g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Plays a role in cell wall integrity. Affects the cell wall
CC       polymer composition in the growing region of the cell (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Bud
CC       membrane {ECO:0000250}; Single-pass type III membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localizes on the
CC       inner surface of the plasma membrane at the bud and in the daughter
CC       cell. Localizes at an incipient bud site in the cells with emerging
CC       buds, a bud tip in small- or medium-budded cells, and a cell periphery
CC       in large-budded cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKG1 family. {ECO:0000305}.
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DR   EMBL; CU928169; CAR23082.1; -; Genomic_DNA.
DR   RefSeq; XP_002553519.1; XM_002553473.1.
DR   AlphaFoldDB; C5DH21; -.
DR   STRING; 559295.C5DH21; -.
DR   EnsemblFungi; CAR23082; CAR23082; KLTH0E00726g.
DR   GeneID; 8291657; -.
DR   KEGG; lth:KLTH0E00726g; -.
DR   eggNOG; ENOG502RZI6; Eukaryota.
DR   HOGENOM; CLU_079389_0_0_1; -.
DR   InParanoid; C5DH21; -.
DR   OMA; KYYVPAY; -.
DR   OrthoDB; 1543691at2759; -.
DR   Proteomes; UP000002036; Chromosome E.
DR   GO; GO:0033101; C:cellular bud membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell membrane; Cell wall biogenesis/degradation; Membrane;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Suppressor of lethality of KEX2 GAS1 double null
FT                   mutant protein 1"
FT                   /id="PRO_0000399670"
FT   TOPO_DOM        1..8
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          41..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  34636 MW;  CB4E62333E9C93B9 CRC64;
     MTDGLGVSVG CAVGIPCGVA VLVAVIFWYY MQRKFKKEIE DDEESMSGDG TISFTNLHSM
     RVPDNPEKDL PVSHVVGGST SSDNTTTAQN VATAGQMEAQ QSQPSKKPKN TYMPAYRKRL
     NSSLSTLQHQ DEQRSPTDSS STSLDTKNQN GRAHSTVLDQ MIPVLAQDDN AAAASSEFSL
     THERTSSNDN LIKNLHNHDF GSYPKRRSSG NLTGMISGNV SSASVHTRTS SVHSGKKNNE
     NVFDTPNSQK FHEAVAPSEE DAESKGMRSY YMLKNNYDVE NASQIAEEDQ YENEFTNYSE
     SKREFINSLR PKKN