ID   SKG1_VANPO              Reviewed;         326 AA.
AC   A7TSZ6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Suppressor of lethality of KEX2 GAS1 double null mutant protein 1;
GN   Name=SKG1; ORFNames=Kpol_304p4;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Plays a role in cell wall integrity. Affects the cell wall
CC       polymer composition in the growing region of the cell (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Bud
CC       membrane {ECO:0000250}; Single-pass type III membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localizes on the
CC       inner surface of the plasma membrane at the bud and in the daughter
CC       cell. Localizes at an incipient bud site in the cells with emerging
CC       buds, a bud tip in small- or medium-budded cells, and a cell periphery
CC       in large-budded cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKG1 family. {ECO:0000305}.
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DR   EMBL; DS480531; EDO14612.1; -; Genomic_DNA.
DR   RefSeq; XP_001642470.1; XM_001642420.1.
DR   AlphaFoldDB; A7TSZ6; -.
DR   STRING; 436907.A7TSZ6; -.
DR   EnsemblFungi; EDO14612; EDO14612; Kpol_304p4.
DR   GeneID; 5542629; -.
DR   KEGG; vpo:Kpol_304p4; -.
DR   eggNOG; ENOG502RZI6; Eukaryota.
DR   HOGENOM; CLU_079389_0_0_1; -.
DR   InParanoid; A7TSZ6; -.
DR   OMA; KYYVPAY; -.
DR   OrthoDB; 1543691at2759; -.
DR   PhylomeDB; A7TSZ6; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0033101; C:cellular bud membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell membrane; Cell wall biogenesis/degradation; Membrane;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..326
FT                   /note="Suppressor of lethality of KEX2 GAS1 double null
FT                   mutant protein 1"
FT                   /id="PRO_0000399671"
FT   TOPO_DOM        1..8
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..326
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          177..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  36744 MW;  7962E28DB997AC53 CRC64;
     MVASNSVAVG CAVGIPVGVG LIIAGCFWLR LQRRFKREDE QDADLQRAVF DEDAYINFES
     MPTLRNNNNN DEDNNDDKRI KKIEENGNEN TIPINDNKEQ RKSKYFVPAY RRKINALSVR
     YDGQQNIEMQ GFGANSSKVS LDSSNAPPKR VISVYDQMVP FVDGDKNSVI QNTELLESND
     SVGNDSTRPS SQANLISNLN SNDFGSYYPR KESFSSINIP HLNTSSPSFT TRPSSVNSMI
     RPNSTDNIFD TPRKSNSDIV SINKDQVNRT GSPVKGTVIS ENMGYKLKNN YNIENSNEIA
     EEDQYENEFT NYSQNKKEFI DSLRPK