ID   BHE22_XENTR             Reviewed;         296 AA.
AC   Q0V9X5; A4IGY1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Class E basic helix-loop-helix protein 22;
DE            Short=bHLHe22;
DE   AltName: Full=Class B basic helix-loop-helix protein 5;
DE            Short=bHLHb5;
GN   Name=bhlhe22; Synonyms=bhlhb5;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC121359; AAI21360.1; -; mRNA.
DR   EMBL; BC135293; AAI35294.1; -; mRNA.
DR   RefSeq; NP_001072933.1; NM_001079465.1.
DR   AlphaFoldDB; Q0V9X5; -.
DR   SMR; Q0V9X5; -.
DR   DNASU; 780395; -.
DR   Ensembl; ENSXETT00000090733; ENSXETP00000091823; ENSXETG00000039790.
DR   GeneID; 780395; -.
DR   KEGG; xtr:780395; -.
DR   CTD; 27319; -.
DR   Xenbase; XB-GENE-6457792; bhlhe22.
DR   InParanoid; Q0V9X5; -.
DR   OrthoDB; 1617813at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000039790; Expressed in brain and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR032654; Bhlhe22.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   PANTHER; PTHR19290:SF52; PTHR19290:SF52; 2.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..296
FT                   /note="Class E basic helix-loop-helix protein 22"
FT                   /id="PRO_0000274288"
FT   DOMAIN          153..207
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          26..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   296 AA;  31322 MW;  B08E1B866EAC96B7 CRC64;
     MERALNLAEE DLFHKSLSAS AKRMESAFRP PQGLDLSQPG DRSPLHCYDG PDPSDLLRHH
     QHHHQASSGA LGAAGANEAL ALAAANMCAK FGESAGRVSV AESSGGEEQS PDDDSDGRCE
     LVLRSAEHRA QAGLKVDAPC ATGGGKKSKE QRTLRLNINA RERRRMHDLN DALDELRAVI
     PYAHSPSVRK LSKIATLLLA KNYILMQAQA LEEMRRLVAY LNQGQAISAA SIPNPAAAAA
     AAAAVALHPA LGAYEPAAAV GYPFSTGLPT ATSCPDKCAL FNNISSSLCK QCTDKP