SKI10_MOUSE
ID SKI10_MOUSE Reviewed; 354 AA.
AC A7TZG1; A7TZG2; Q8CAZ8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Selection and upkeep of intraepithelial T-cells protein 10;
DE Short=Skint-10;
DE Flags: Precursor;
GN Name=Skint10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J, and FVB/NJ;
RX PubMed=18408721; DOI=10.1038/ng.108;
RA Boyden L.M., Lewis J.M., Barbee S.D., Bas A., Girardi M., Hayday A.C.,
RA Tigelaar R.E., Lifton R.P.;
RT "Skint1, the prototype of a newly identified immunoglobulin superfamily
RT gene cluster, positively selects epidermal gammadelta T cells.";
RL Nat. Genet. 40:656-662(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC cells in the embryonic thymus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in skin and thymus.
CC {ECO:0000269|PubMed:18408721}.
CC -!- MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered
CC in the D1 region of the chromosome 4.
CC -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABS30727.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=ABS30728.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF494905; ABS30727.1; ALT_INIT; mRNA.
DR EMBL; EF494906; ABS30728.1; ALT_INIT; mRNA.
DR EMBL; AK037152; BAC29723.1; -; mRNA.
DR EMBL; AL645508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38841.1; -.
DR RefSeq; NP_808336.1; NM_177668.2.
DR AlphaFoldDB; A7TZG1; -.
DR SMR; A7TZG1; -.
DR GlyGen; A7TZG1; 1 site.
DR PaxDb; A7TZG1; -.
DR PRIDE; A7TZG1; -.
DR ProteomicsDB; 261373; -.
DR Ensembl; ENSMUST00000060327; ENSMUSP00000058838; ENSMUSG00000048766.
DR GeneID; 230613; -.
DR KEGG; mmu:230613; -.
DR UCSC; uc008udy.1; mouse.
DR CTD; 230613; -.
DR MGI; MGI:2685416; Skint10.
DR VEuPathDB; HostDB:ENSMUSG00000048766; -.
DR eggNOG; ENOG502THRH; Eukaryota.
DR GeneTree; ENSGT00940000165990; -.
DR HOGENOM; CLU_871423_0_0_1; -.
DR InParanoid; A7TZG1; -.
DR OMA; WLWDICI; -.
DR OrthoDB; 970395at2759; -.
DR PhylomeDB; A7TZG1; -.
DR TreeFam; TF339324; -.
DR BioGRID-ORCS; 230613; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Skint10; mouse.
DR PRO; PR:A7TZG1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A7TZG1; protein.
DR Bgee; ENSMUSG00000048766; Expressed in skin of external ear and 16 other tissues.
DR ExpressionAtlas; A7TZG1; baseline and differential.
DR Genevisible; A7TZG1; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..52
FT /evidence="ECO:0000255"
FT CHAIN 53..354
FT /note="Selection and upkeep of intraepithelial T-cells
FT protein 10"
FT /id="PRO_5000270116"
FT TOPO_DOM 53..158
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..252
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..354
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 53..141
FT /note="Ig-like V-type"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 71..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 27
FT /note="S -> P (in Ref. 1; ABS30728)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="V -> I (in Ref. 1; ABS30728)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="E -> K (in Ref. 1; ABS30728)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="I -> L (in Ref. 1; ABS30728)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="F -> S (in Ref. 1; ABS30728)"
FT /evidence="ECO:0000305"
FT CONFLICT 334
FT /note="I -> E (in Ref. 1; ABS30728)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 354 AA; 40861 MW; A58C6BDEFF7912BF CRC64;
MFLRTQMEQS QADIFALIKP HFGVMESSAS YLPGFFMTFL LLQTTVLTQA MSLDIQINIQ
VPDTEGVLLE CTSGSLIPPA EMTWRDSKGN IIPHSTTFDS QDRAGLLYLK SSILLKNRVQ
SPITCSIYNV TTNREKKRSV VLPDILFKSE YMSLMSNKFS CPLTYLFIII FLNCLKGMLD
FCCLKGKPVY FRELINKIKE VLNIKMRACC TLIWEFLLIV LYIAFLPFYL KFRSRASILD
DAYPLHSNWL WDICIVLSVL MIFFTGLSLF LLWTLNCYGQ MSYLPSMSMD LSKHDFEQNS
SKSSEFQENY DVSCEIFLGT FEETIFSQHQ ESCIEDSFNP LQPLRLDCSL NWKT
