SKI11_ARATH
ID SKI11_ARATH Reviewed; 467 AA.
AC Q8L736; B9DGL2; O80606;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=F-box/kelch-repeat protein SKIP11;
DE AltName: Full=SKP1-interacting partner 11;
GN Name=SKIP11; OrderedLocusNames=At2g02870; ORFNames=T17M13.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP INTERACTION WITH SKP1A/ASK1 AND SPK1B/ASK2.
RX PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT Arabidopsis.";
RL Plant J. 34:753-767(2003).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with SKP1A/ASK1 and SPK1B/ASK2. {ECO:0000250,
CC ECO:0000269|PubMed:12795696}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250}.
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DR EMBL; AC004138; AAC32908.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05636.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05637.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05638.1; -; Genomic_DNA.
DR EMBL; AY060567; AAL31196.1; -; mRNA.
DR EMBL; AY139977; AAM98120.1; -; mRNA.
DR EMBL; BT002216; AAN72228.1; -; mRNA.
DR EMBL; AK317194; BAH19879.1; -; mRNA.
DR PIR; H84441; H84441.
DR RefSeq; NP_001030959.1; NM_001035882.1.
DR RefSeq; NP_001030960.1; NM_001035883.2.
DR RefSeq; NP_178390.1; NM_126342.4.
DR AlphaFoldDB; Q8L736; -.
DR SMR; Q8L736; -.
DR BioGRID; 220; 2.
DR IntAct; Q8L736; 2.
DR STRING; 3702.AT2G02870.1; -.
DR PaxDb; Q8L736; -.
DR PRIDE; Q8L736; -.
DR ProteomicsDB; 234529; -.
DR EnsemblPlants; AT2G02870.1; AT2G02870.1; AT2G02870.
DR EnsemblPlants; AT2G02870.2; AT2G02870.2; AT2G02870.
DR EnsemblPlants; AT2G02870.3; AT2G02870.3; AT2G02870.
DR GeneID; 814818; -.
DR Gramene; AT2G02870.1; AT2G02870.1; AT2G02870.
DR Gramene; AT2G02870.2; AT2G02870.2; AT2G02870.
DR Gramene; AT2G02870.3; AT2G02870.3; AT2G02870.
DR KEGG; ath:AT2G02870; -.
DR Araport; AT2G02870; -.
DR TAIR; locus:2056705; AT2G02870.
DR eggNOG; KOG1072; Eukaryota.
DR HOGENOM; CLU_028510_0_1_1; -.
DR InParanoid; Q8L736; -.
DR OMA; DVIEHWI; -.
DR OrthoDB; 1562595at2759; -.
DR PhylomeDB; Q8L736; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q8L736; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8L736; baseline and differential.
DR Genevisible; Q8L736; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.120.10.80; -; 1.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR Pfam; PF01344; Kelch_1; 2.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF117281; SSF117281; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..467
FT /note="F-box/kelch-repeat protein SKIP11"
FT /id="PRO_0000283191"
FT DOMAIN 116..163
FT /note="F-box"
FT REPEAT 159..210
FT /note="Kelch 1"
FT REPEAT 215..259
FT /note="Kelch 2"
FT REPEAT 261..307
FT /note="Kelch 3"
FT REPEAT 308..356
FT /note="Kelch 4"
FT REPEAT 365..411
FT /note="Kelch 5"
FT REGION 77..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 394
FT /note="V -> I (in Ref. 3; AAM98120)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 467 AA; 51698 MW; 17229589475E13C2 CRC64;
MLEDRSPDSC LSTRVFSSSR LSESNWSNSY MYPEDDDKLL GNGKRALEVV GEVRQTKSLK
LMGFSIIYDS DSSDYSLSGG EEQADAAIGD GSSSRQEQEQ QSDFNDNGGD SSDSHSLINE
IGRDNSIDCL IRCSRSDYGS IASLNRNFRS LVKSGEIYRL RRQNGFVEHW VYFSCQLLEW
VAFDPVERRW MQLPTMPSSV TFMCADKESL AVGTDLLVLG KDDFSSHVIY RYSLLTNSWS
SGMKMNSPRC LFGSASLGEI AIFAGGCDSQ GKILDFAEMY NSELQTWITL PRMNKPRKMC
SGVFMDGKFY VIGGIGGADS KGLTCGEEYD LETKKWTQIP DLSPPRSRAD QADMSPAAEA
PPLVAVVNNQ LYAADHADME VRKYDKENKK WLTVGRLPER AGSVNGWGLA FRACGERLIV
IGGPKCSGGG FIELNSWIPS DGGPPQWTLL DRKHSPTFVY NCAVMGC
