ID   SKI11_MOUSE             Reviewed;         364 AA.
AC   A7XV14;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Selection and upkeep of intraepithelial T-cells protein 11;
DE            Short=Skint-11;
DE   Flags: Precursor;
GN   Name=Skint11;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Boyden L.M., Lifton R.P.;
RT   "A new family of genes on mouse chromosome 4.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC       cells in the embryonic thymus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in skin and thymus.
CC   -!- MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered
CC       in the D1 region of the chromosome 4.
CC   -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
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DR   EMBL; EU099309; ABU87907.1; -; mRNA.
DR   CCDS; CCDS51270.1; -.
DR   RefSeq; NP_001159499.1; NM_001166027.1.
DR   AlphaFoldDB; A7XV14; -.
DR   SMR; A7XV14; -.
DR   PaxDb; A7XV14; -.
DR   PRIDE; A7XV14; -.
DR   DNASU; 230623; -.
DR   Ensembl; ENSMUST00000164297; ENSMUSP00000127138; ENSMUSG00000057977.
DR   GeneID; 230623; -.
DR   KEGG; mmu:230623; -.
DR   UCSC; uc012div.1; mouse.
DR   CTD; 230623; -.
DR   MGI; MGI:2685415; Skint11.
DR   VEuPathDB; HostDB:ENSMUSG00000057977; -.
DR   GeneTree; ENSGT00940000165990; -.
DR   HOGENOM; CLU_871423_0_0_1; -.
DR   OrthoDB; 970395at2759; -.
DR   PhylomeDB; A7XV14; -.
DR   BioGRID-ORCS; 230623; 1 hit in 71 CRISPR screens.
DR   PRO; PR:A7XV14; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; A7XV14; protein.
DR   Bgee; ENSMUSG00000057977; Expressed in zone of skin and 6 other tissues.
DR   ExpressionAtlas; A7XV14; differential.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..364
FT                   /note="Selection and upkeep of intraepithelial T-cells
FT                   protein 11"
FT                   /id="PRO_5000271645"
FT   TOPO_DOM        29..138
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..186
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        208..230
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        252..364
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          29..118
FT                   /note="Ig-like V-type"
FT   DISULFID        48..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   364 AA;  42262 MW;  F364ED22DBABBB6C CRC64;
     MEPSASCLPG FFMVCILLKI TVLTQVMSLD IQINTQIPDT EEGVLVECTA ESLFPPAEMT
     WRDSKGNIIP PSSTFDSQDR AGLLCLKSTI LLKNRTEGPI TCSIYNKTTN QEKRRSIILS
     DVLFRPQYMS LMSNNLLYLG IYLIFILFLN FLKGILFCLT KRLVHFRKRM IKIKKVWSNK
     TRACCPLIWE FLEIVLFIAF LPLYLMFRIR VFTLDEAHIL YNNWLWKVCK TLIAMMILFT
     VLILFLLWTL NRYGKMPCLS SMNIDVSTHD AEQNSSKSAK FQENYDVAGQ MILETYEETI
     FCQHQESCEE YNYDPLLLSS LDALGTCEDE KFSQHQESFE EDEDLQSFSD FKIELYSKLG
     NLTH