ID   SKI16_ARATH             Reviewed;         436 AA.
AC   Q9LND7;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=F-box protein SKIP16;
DE   AltName: Full=SKP1-interacting partner 16;
GN   Name=SKIP16; OrderedLocusNames=At1g06110; ORFNames=T21E18.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2; ASK4; ASK11 AND ASK13.
RX   PubMed=12169662; DOI=10.1073/pnas.162339999;
RA   Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.;
RT   "The F-box subunit of the SCF E3 complex is encoded by a diverse
RT   superfamily of genes in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002).
RN   [5]
RP   INTERACTION WITH SKPIB/ASK2.
RX   PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA   Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA   Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT   "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT   Arabidopsis.";
RL   Plant J. 34:753-767(2003).
CC   -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC       complexes, which may mediate the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC       similarity). Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK4, ASK11 and
CC       ASK13. {ECO:0000250, ECO:0000269|PubMed:12169662,
CC       ECO:0000269|PubMed:12795696}.
CC   -!- INTERACTION:
CC       Q9LND7; Q9FHW7: SKP1B; NbExp=3; IntAct=EBI-591078, EBI-604076;
CC   -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC       {ECO:0000250}.
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DR   EMBL; AC024174; AAF80134.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE27940.1; -; Genomic_DNA.
DR   EMBL; AF419599; AAL31931.1; -; mRNA.
DR   EMBL; AY099571; AAM20423.1; -; mRNA.
DR   EMBL; BT002142; AAN72153.1; -; mRNA.
DR   PIR; D86196; D86196.
DR   RefSeq; NP_563759.1; NM_100492.4.
DR   AlphaFoldDB; Q9LND7; -.
DR   SMR; Q9LND7; -.
DR   BioGRID; 22362; 3.
DR   IntAct; Q9LND7; 7.
DR   STRING; 3702.AT1G06110.1; -.
DR   PaxDb; Q9LND7; -.
DR   PRIDE; Q9LND7; -.
DR   ProteomicsDB; 234566; -.
DR   EnsemblPlants; AT1G06110.1; AT1G06110.1; AT1G06110.
DR   GeneID; 837120; -.
DR   Gramene; AT1G06110.1; AT1G06110.1; AT1G06110.
DR   KEGG; ath:AT1G06110; -.
DR   Araport; AT1G06110; -.
DR   TAIR; locus:2198826; AT1G06110.
DR   eggNOG; KOG4408; Eukaryota.
DR   HOGENOM; CLU_050311_0_0_1; -.
DR   InParanoid; Q9LND7; -.
DR   OMA; YRDLVSC; -.
DR   OrthoDB; 506060at2759; -.
DR   PhylomeDB; Q9LND7; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9LND7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9LND7; baseline and differential.
DR   Genevisible; Q9LND7; AT.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IPI:TAIR.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.40.1470; -; 1.
DR   InterPro; IPR007474; ApaG_domain.
DR   InterPro; IPR036767; ApaG_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR018958; Knr4/Smi1-like_dom.
DR   InterPro; IPR037883; Knr4/Smi1-like_sf.
DR   Pfam; PF04379; DUF525; 1.
DR   Pfam; PF09346; SMI1_KNR4; 1.
DR   SUPFAM; SSF110069; SSF110069; 1.
DR   SUPFAM; SSF160631; SSF160631; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS51087; APAG; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..436
FT                   /note="F-box protein SKIP16"
FT                   /id="PRO_0000375238"
FT   DOMAIN          75..111
FT                   /note="F-box; degenerate"
FT   DOMAIN          295..436
FT                   /note="ApaG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00412"
SQ   SEQUENCE   436 AA;  48976 MW;  2FF2D4AAC5478259 CRC64;
     MGLEDAGDLV LHIVLSKIGP ENTARVACVS KRLKVSASEE SLWSIFCSND LNISTPLDPH
     GDPAPSFKRA YQLWRESFRM YPWNLVKRVR LCWDNLKQWL TLNFPEAKAT LRKGVTEDDL
     QEFETSLKVK LPLPTRLLYR FVDGQELSSP NGLDGSLGLI GGYSAYSHDV NVYLLPLKEV
     MRETKESFMR DLGFSSRLDL IVMAASVVAS LKIFLLDCTT GQLFTGTSNR QLLPCVPDAL
     VRSVHDTNGD QQQDAMLLWL EEHGRRLQTG TINVRQQNNV KSISLFPEIP PLCSVSVTNG
     VQVRASSVFI PEISNLRDQP PAYWYAYSIR MSLMPEGCIL NGTHHSSCQL YWRHWVIRAD
     NEVIDNVNGE AVIGKYPLLQ AGEEEFVYES CSSFPTTAGS IDGSFTFVPG SLRDPKGSQF
     EVKVVEFPLE LPDYIF