ID   SKI23_ARATH             Reviewed;         407 AA.
AC   Q3EBZ2; Q0WRT1; Q7XJL8;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=F-box protein SKIP23;
DE   AltName: Full=SKP1-interacting partner 23;
GN   Name=SKIP23; OrderedLocusNames=At2g17030; ORFNames=F6P23.19;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-407.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   INTERACTION WITH SKP1A/ASK1.
RX   PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA   Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA   Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT   "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT   Arabidopsis.";
RL   Plant J. 34:753-767(2003).
CC   -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC       complexes, which may mediate the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC       similarity). Interacts with SKP1A/ASK1. {ECO:0000250,
CC       ECO:0000269|PubMed:12795696}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC       {ECO:0000250}.
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DR   EMBL; CP002685; AEC06574.1; -; Genomic_DNA.
DR   EMBL; AK228215; BAF00168.1; -; mRNA.
DR   EMBL; BT029773; ABM06043.1; -; mRNA.
DR   PIR; C84547; C84547.
DR   RefSeq; NP_565401.1; NM_127256.5.
DR   AlphaFoldDB; Q3EBZ2; -.
DR   BioGRID; 1563; 15.
DR   STRING; 3702.AT2G17030.1; -.
DR   PaxDb; Q3EBZ2; -.
DR   PRIDE; Q3EBZ2; -.
DR   ProteomicsDB; 234583; -.
DR   EnsemblPlants; AT2G17030.1; AT2G17030.1; AT2G17030.
DR   GeneID; 816206; -.
DR   Gramene; AT2G17030.1; AT2G17030.1; AT2G17030.
DR   KEGG; ath:AT2G17030; -.
DR   Araport; AT2G17030; -.
DR   TAIR; locus:2827656; AT2G17030.
DR   eggNOG; ENOG502QW71; Eukaryota.
DR   HOGENOM; CLU_019286_1_0_1; -.
DR   OMA; WLVKIEE; -.
DR   OrthoDB; 943581at2759; -.
DR   PhylomeDB; Q3EBZ2; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q3EBZ2; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q3EBZ2; baseline and differential.
DR   Genevisible; Q3EBZ2; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016567; P:protein ubiquitination; IDA:TAIR.
DR   InterPro; IPR005174; DUF295.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   Pfam; PF03478; DUF295; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..407
FT                   /note="F-box protein SKIP23"
FT                   /id="PRO_0000274949"
FT   DOMAIN          2..50
FT                   /note="F-box"
SQ   SEQUENCE   407 AA;  46228 MW;  F3B451248F6C9E4B CRC64;
     MVDWSTLPKD LLDLISKSLE SSFDLIQFRS VCSSWRSAAE PKSPLPTHHL PILPDNGGSL
     FPDSAVGFRL SQRSILLIKP HEPCIESDSF GWLIKVEEDL NVPRKVTLLD PLCDTRNSIP
     ENFPRVLDMS KFKVRELGRE FKLHYFNTVG DIVESLYLEK AVVKYLDCDG DYKFVLLTIH
     VSGKLAVFRS WDRAWTVIND MPSPYDDVML FDGRFFAVDN NGRTVVVDYS SLKLTLVASP
     VFGGDKKFLI ESCGEMLLVD MYLSLEAVEG DPGFVEEIFE HPAFYMNERT VKFKVYRFVE
     REESWVDVYD LEDKMLFLGD DSTFSASASD ILPLCDGSSV FFNGNVFNGE DLGAMQDRDL
     GVFDFRSGKI ELVQKLPEYA KLFWPPPPWI TSHARAEDHI GETSSQS