SKI3_SCHPO
ID SKI3_SCHPO Reviewed; 1389 AA.
AC O94474;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Superkiller protein 3;
GN Name=ski3; ORFNames=SPCC1919.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of the SKI complex involved in 3'-mRNA degradation
CC pathway. {ECO:0000250}.
CC -!- SUBUNIT: Component of the SKI complex composed of at least ski2, ski3
CC and ski8. The SKI complex interacts with ski7, which makes the link
CC between the SKI complex and the exosome in order to perform mRNA
CC degradation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA22636.1; -; Genomic_DNA.
DR PIR; T41230; T41230.
DR RefSeq; NP_588487.1; NM_001023478.2.
DR AlphaFoldDB; O94474; -.
DR SMR; O94474; -.
DR BioGRID; 275708; 73.
DR STRING; 4896.SPCC1919.05.1; -.
DR iPTMnet; O94474; -.
DR MaxQB; O94474; -.
DR PaxDb; O94474; -.
DR PRIDE; O94474; -.
DR EnsemblFungi; SPCC1919.05.1; SPCC1919.05.1:pep; SPCC1919.05.
DR GeneID; 2539136; -.
DR KEGG; spo:SPCC1919.05; -.
DR PomBase; SPCC1919.05; ski3.
DR VEuPathDB; FungiDB:SPCC1919.05; -.
DR eggNOG; KOG1127; Eukaryota.
DR HOGENOM; CLU_001688_2_0_1; -.
DR InParanoid; O94474; -.
DR OMA; FNLWKAV; -.
DR PhylomeDB; O94474; -.
DR Reactome; R-SPO-429958; mRNA decay by 3' to 5' exoribonuclease.
DR PRO; PR:O94474; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0055087; C:Ski complex; ISO:PomBase.
DR GO; GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; ISO:PomBase.
DR GO; GO:0034427; P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; IBA:GO_Central.
DR GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; ISO:PomBase.
DR Gene3D; 1.25.40.10; -; 5.
DR InterPro; IPR039226; Ski3/TTC37.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR040962; TPR_22.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15704; PTHR15704; 1.
DR Pfam; PF18833; TPR_22; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 14.
DR SUPFAM; SSF48452; SSF48452; 5.
DR PROSITE; PS50005; TPR; 13.
DR PROSITE; PS50293; TPR_REGION; 5.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1389
FT /note="Superkiller protein 3"
FT /id="PRO_0000311765"
FT REPEAT 2..35
FT /note="TPR 1"
FT REPEAT 36..69
FT /note="TPR 2"
FT REPEAT 90..123
FT /note="TPR 3"
FT REPEAT 381..414
FT /note="TPR 4"
FT REPEAT 429..463
FT /note="TPR 5"
FT REPEAT 465..497
FT /note="TPR 6"
FT REPEAT 498..530
FT /note="TPR 7"
FT REPEAT 538..574
FT /note="TPR 8"
FT REPEAT 575..608
FT /note="TPR 9"
FT REPEAT 650..683
FT /note="TPR 10"
FT REPEAT 684..717
FT /note="TPR 11"
FT REPEAT 719..751
FT /note="TPR 12"
FT REPEAT 759..792
FT /note="TPR 13"
FT REPEAT 931..963
FT /note="TPR 14"
FT REPEAT 964..997
FT /note="TPR 15"
FT REPEAT 999..1031
FT /note="TPR 16"
FT REPEAT 1124..1157
FT /note="TPR 17"
FT REPEAT 1167..1200
FT /note="TPR 18"
FT REGION 326..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 157876 MW; FC5C9A785034AFE0 CRC64;
MAKPALKAAK EALVVKNYEL AIEQSKKALS FDANNYNANV FLGVAYFSTK QLSESKEAYL
DAIKIDEKAV LAWQGLWNLY ESTHDISELH KITPILASKF LELEEQNKCL NTVNKYMEVV
KKYGNKADEF KALKLLTPEE GEIYEYLEGR VLPLQTVYMQ MVDIQESMDR CYFESEVNKR
KTRLGARLEQ VMRDVELEIY KDSPLETLYN QIINYAETDE IRRLTESKLL HMYNKLLILS
EIKEKSHWRE RIWDLIQGMV TLHIPEQAAW TIYFEWQDHS DISFFQSAEL QEYIELFPGS
PLAQALFAFR NSDLWHKEHP IQLEDSNNSA ELAKETKEED DSENSVDKKE NEEDIISSTM
MPQDEVLANL TEAYENAPQS TIISECLAKY YIHLKEYEYA IGLSKAALEV LKRLQQDTGV
KLDKLTRIFQ LCLAIGYSHY EVPRYLFQAM HYYDILLAAD PRNYHALLGK GLVQIENEQY
SDAVKTLGLL LDDHENDPSL SELSWCYFKT GNLPKAISTV EKCLDVLLSM DVERFKIAEA
YYRYGIYILN RKSENYLEDS FSAFVSSLRK DPNYAPAYTS LGLYYRDIHD MVRATKCFQK
AFELDASQVE AAEALAKTFA EANEWELVEV ISRRVLNTSE NDLKRKKKFN WHHTSLGVLE
LNAKNFHKAI VHFQSALRIS PKDTNAWSGL GEAYARSGRY VSALKAFNRA SILDPDDWYV
KYFIATLEKD MGEYEVAVST LSEILAVRSK ELCVQVSLAE TYVRLAKLYH ARGFYSRAAD
SLEKSIQICC NVLKEDITSI FSWEILGDAC LSFCQLKNYH NRFPNSLISD ILFTTEAMKC
ANNGRQFENM IYLPDLETSS GAIFIAAVAI TCFTIHLSLV ADDKLLLPVS WYNLGSSYYR
FYECDTTKDA TLQVAINCIK QAIKLEAKNY VFWNMLGVLF SQTKAVRSAQ HCYIQSLLLN
ERSSGVWANY GALCIQNHDV ECANAAFTRS ISIDPDNSQA WLGKAYCSIA VGSIRKAVQI
IHHAFEISSG KMPDVNYWYA DTMLHAVNTE DFVTTDGDIW SATYAIKRYL GENPTDTFAY
YIKASLLEHL GETTDSVPSA IRLCELLEQE YDVSESPVIL KRFIDAKALL GRLYLAKKSF
ENSVEQAGIA LDLLEGEEDE DIKRTTLGLN LTCGTASFFL NKLEKSLDCF EKALLVSDSN
ADVVVLVSKV LWALGSENGK QAAREQLFEA LEQSPSHIGS LLCLGAIAIY DEDDAVCSAI
EDSIAHLKKD EVLRSGALKQ VQIMEVLLTK KIDESMIKSL LQRFLHVYPF AASSWTLLTN
RYASKSLANA FATTLYTHPS RPDDLAQSYR LQNSIDRAQV AIHLVPWDSA NWKALHGVTH
EALVSSDAS
