SKIP1_ARATH
ID SKIP1_ARATH Reviewed; 300 AA.
AC Q9FDX1;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=F-box protein SKIP1;
DE AltName: Full=SKP1-interacting partner 1;
GN Name=SKIP1; OrderedLocusNames=At5g57900; ORFNames=MTI20.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH SKP1A/ASK1.
RX PubMed=11387208; DOI=10.1093/emboj/20.11.2742;
RA Farras R., Ferrando A., Jasik J., Kleinow T., Oekresz L., Tiburcio A.,
RA Salchert K., del Pozo C., Schell J., Koncz C.;
RT "SKP1-SnRK protein kinase interactions mediate proteasomal binding of a
RT plant SCF ubiquitin ligase.";
RL EMBO J. 20:2742-2756(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INTERACTION WITH SKP1A/ASK1 AND SPK1B/ASK2.
RX PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT Arabidopsis.";
RL Plant J. 34:753-767(2003).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with SKP1A/ASK1 and SKP1B/ASK2. {ECO:0000250,
CC ECO:0000269|PubMed:11387208, ECO:0000269|PubMed:12795696}.
CC -!- INTERACTION:
CC Q9FDX1; Q39255: SKP1A; NbExp=5; IntAct=EBI-604228, EBI-532357;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250}.
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DR EMBL; AF263377; AAG21976.1; -; mRNA.
DR EMBL; AB013396; BAB08860.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96969.1; -; Genomic_DNA.
DR EMBL; AK229464; BAF01322.1; -; mRNA.
DR EMBL; BT026067; ABG48423.1; -; mRNA.
DR RefSeq; NP_568870.1; NM_125175.2.
DR AlphaFoldDB; Q9FDX1; -.
DR SMR; Q9FDX1; -.
DR BioGRID; 21145; 4.
DR IntAct; Q9FDX1; 3.
DR STRING; 3702.AT5G57900.1; -.
DR PaxDb; Q9FDX1; -.
DR PRIDE; Q9FDX1; -.
DR ProteomicsDB; 232558; -.
DR EnsemblPlants; AT5G57900.1; AT5G57900.1; AT5G57900.
DR GeneID; 835901; -.
DR Gramene; AT5G57900.1; AT5G57900.1; AT5G57900.
DR KEGG; ath:AT5G57900; -.
DR Araport; AT5G57900; -.
DR TAIR; locus:2174398; AT5G57900.
DR eggNOG; KOG1947; Eukaryota.
DR HOGENOM; CLU_044915_3_1_1; -.
DR InParanoid; Q9FDX1; -.
DR OMA; VCKSWLQ; -.
DR OrthoDB; 1046098at2759; -.
DR PhylomeDB; Q9FDX1; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9FDX1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FDX1; baseline and differential.
DR Genevisible; Q9FDX1; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IDA:TAIR.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 1.
DR SMART; SM00367; LRR_CC; 3.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..300
FT /note="F-box protein SKIP1"
FT /id="PRO_0000272203"
FT DOMAIN 11..52
FT /note="F-box; degenerate"
SQ SEQUENCE 300 AA; 34565 MW; F629B3595DCF5EC5 CRC64;
MEEDGSDWGG LAPEILINII SRLTIQELWT GPMFVQKSWL TVCRDPYLWS IFDLEPWFDS
YPESTHLWSP EFEQKVDLML RSVVDWSEGG LTKIRVRHCS DHALSYAADR CPNLQVLAIR
SSPNVTDASM TKIAFRCRSL KELDISYCHE ISHDTLVMIG RNCPNLRILK RNLMDWSSRH
IGSVPTEYLD ACPQDGDTEA DAIGKHMINL EHLEIQFSRL SVKGLASICE GCPKLEYLDL
FGCVHLSSRD ITSNVSRLKW LKEVKKPDVY VPRSGDVAQT ERYGHWRLYD ERFDIQAMRI
