SKIP4_ARATH
ID SKIP4_ARATH Reviewed; 358 AA.
AC Q9M2C9; Q8GW14; Q9FV01;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=F-box/kelch-repeat protein SKIP4;
DE AltName: Full=SKP1-interacting partner 4;
GN Name=SKIP4; OrderedLocusNames=At3g61350; ORFNames=T20K12.250;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-358, AND INTERACTION WITH SKP1A/ASK1.
RX PubMed=11387208; DOI=10.1093/emboj/20.11.2742;
RA Farras R., Ferrando A., Jasik J., Kleinow T., Oekresz L., Tiburcio A.,
RA Salchert K., del Pozo C., Schell J., Koncz C.;
RT "SKP1-SnRK protein kinase interactions mediate proteasomal binding of a
RT plant SCF ubiquitin ligase.";
RL EMBO J. 20:2742-2756(2001).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with SKP1A/ASK1. {ECO:0000250,
CC ECO:0000269|PubMed:11387208}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG21979.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL137898; CAB71065.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80189.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65048.1; -; Genomic_DNA.
DR EMBL; AK119147; BAC43717.1; -; mRNA.
DR EMBL; BT025245; ABF18998.1; -; mRNA.
DR EMBL; AF263380; AAG21979.1; ALT_INIT; mRNA.
DR PIR; T47927; T47927.
DR RefSeq; NP_001327045.1; NM_001340087.1.
DR RefSeq; NP_567112.1; NM_115999.5.
DR AlphaFoldDB; Q9M2C9; -.
DR SMR; Q9M2C9; -.
DR BioGRID; 10621; 1.
DR STRING; 3702.AT3G61350.1; -.
DR PaxDb; Q9M2C9; -.
DR PRIDE; Q9M2C9; -.
DR ProteomicsDB; 232622; -.
DR EnsemblPlants; AT3G61350.1; AT3G61350.1; AT3G61350.
DR EnsemblPlants; AT3G61350.2; AT3G61350.2; AT3G61350.
DR GeneID; 825307; -.
DR Gramene; AT3G61350.1; AT3G61350.1; AT3G61350.
DR Gramene; AT3G61350.2; AT3G61350.2; AT3G61350.
DR KEGG; ath:AT3G61350; -.
DR Araport; AT3G61350; -.
DR TAIR; locus:2098926; AT3G61350.
DR eggNOG; KOG1072; Eukaryota.
DR HOGENOM; CLU_776956_0_0_1; -.
DR InParanoid; Q9M2C9; -.
DR OMA; DMASGWR; -.
DR OrthoDB; 704070at2759; -.
DR PhylomeDB; Q9M2C9; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9M2C9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M2C9; baseline and differential.
DR Genevisible; Q9M2C9; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0009409; P:response to cold; IEP:TAIR.
DR Gene3D; 2.120.10.80; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR SMART; SM00612; Kelch; 2.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..358
FT /note="F-box/kelch-repeat protein SKIP4"
FT /id="PRO_0000272226"
FT DOMAIN 20..67
FT /note="F-box"
FT REPEAT 78..122
FT /note="Kelch 1"
FT REPEAT 123..171
FT /note="Kelch 2"
FT REPEAT 173..219
FT /note="Kelch 3"
FT REPEAT 220..269
FT /note="Kelch 4"
FT REPEAT 271..307
FT /note="Kelch 5"
FT REPEAT 308..355
FT /note="Kelch 6"
FT CONFLICT 329
FT /note="N -> S (in Ref. 3; BAC43717)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 358 AA; 40118 MW; 3A7B20C35C31B27D CRC64;
MACIVEDPQR AGQSNETQIA LISGVPDDIS KSCLARVPRE YHMAMKCVSR RWRDFVCSDE
MCDYRNEFNL AESWIYALCR DISGGVFLHM LNPFSSRRSW KRINDYPYIP MREGMGFAVL
GKRLFVLGGC GWLEDATDEI YCYDAAMNTW FDVVPPLSTK RCYFACETLD GKIIAIGGLG
LNPNAKRTWD IYDPLTRTCK SCSDVNIVPE MEDSFVMDGR IYIRGGVGGS STAVYSASSG
IWERMDDDMA SGWRGPAVVV AGDLYVLDQT FGAKLTMWCK DTRMWIHIGK LSQLVMKQPC
RLVSIGNSIF VIGKDCSTVV IDVENVRKNK MNGVMVCSSI PKTWDDDIDV ISCKSVAI
