SKIP6_ARATH
ID SKIP6_ARATH Reviewed; 372 AA.
AC Q9SJ04; Q9FUZ9;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=F-box/kelch-repeat protein SKIP6;
DE AltName: Full=SKP1-interacting partner 6;
GN Name=SKIP6; OrderedLocusNames=At2g21950; ORFNames=F7D8.27;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-163, AND INTERACTION WITH SKP1A/ASK1.
RX PubMed=11387208; DOI=10.1093/emboj/20.11.2742;
RA Farras R., Ferrando A., Jasik J., Kleinow T., Oekresz L., Tiburcio A.,
RA Salchert K., del Pozo C., Schell J., Koncz C.;
RT "SKP1-SnRK protein kinase interactions mediate proteasomal binding of a
RT plant SCF ubiquitin ligase.";
RL EMBO J. 20:2742-2756(2001).
RN [5]
RP INTERACTION WITH SKP1A/ASK1.
RX PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT Arabidopsis.";
RL Plant J. 34:753-767(2003).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with SKP1A/ASK1. {ECO:0000250,
CC ECO:0000269|PubMed:11387208, ECO:0000269|PubMed:12795696}.
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DR EMBL; AC007019; AAD20412.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07245.1; -; Genomic_DNA.
DR EMBL; AY091137; AAM14086.1; -; mRNA.
DR EMBL; AY122967; AAM67500.1; -; mRNA.
DR EMBL; AF263382; AAG21981.1; -; mRNA.
DR PIR; B84607; B84607.
DR RefSeq; NP_565522.1; NM_127764.2.
DR AlphaFoldDB; Q9SJ04; -.
DR SMR; Q9SJ04; -.
DR BioGRID; 2084; 1.
DR IntAct; Q9SJ04; 2.
DR STRING; 3702.AT2G21950.1; -.
DR PaxDb; Q9SJ04; -.
DR PRIDE; Q9SJ04; -.
DR ProteomicsDB; 228438; -.
DR EnsemblPlants; AT2G21950.1; AT2G21950.1; AT2G21950.
DR GeneID; 816731; -.
DR Gramene; AT2G21950.1; AT2G21950.1; AT2G21950.
DR KEGG; ath:AT2G21950; -.
DR Araport; AT2G21950; -.
DR TAIR; locus:2052596; AT2G21950.
DR eggNOG; KOG1072; Eukaryota.
DR HOGENOM; CLU_032521_1_2_1; -.
DR InParanoid; Q9SJ04; -.
DR OMA; GLPKFLC; -.
DR OrthoDB; 1025357at2759; -.
DR PhylomeDB; Q9SJ04; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9SJ04; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJ04; baseline and differential.
DR Genevisible; Q9SJ04; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.120.10.80; -; 1.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR SMART; SM00612; Kelch; 2.
DR SUPFAM; SSF117281; SSF117281; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..372
FT /note="F-box/kelch-repeat protein SKIP6"
FT /id="PRO_0000272228"
FT DOMAIN 19..66
FT /note="F-box"
FT REPEAT 127..173
FT /note="Kelch 1"
FT REPEAT 175..226
FT /note="Kelch 2"
FT REPEAT 228..260
FT /note="Kelch 3"
FT REPEAT 261..307
FT /note="Kelch 4"
SQ SEQUENCE 372 AA; 41294 MW; 9B0089976AC30898 CRC64;
MAATTSSGDE PPETKSPAQL IPLLSEDVAL SCLARVPRCH YPILSLVSKT FRSLPTSPLL
YATRALVGAT ENILYVAIRI PPESGACWFT LLHRTLSNST NSKMLVPIPS CPSPSLVGSA
YVVVDSEIYV IGGSIRDVPS SSVWVLDCRF HTWRRVSNMR VGREFAAAGV IDGKIYVIGG
CVVDNWARSI NWAEMFDIKT QTWEPVASPG MEVREKWMHA SAVMEGKVYA MADRNGVVYE
PKEKKWEMPE KRLDLGWRGR ACVIENILYC YDYLGKIRGY DPKERIWREL KGVESLPKFL
CGATMANRGG KLTVLWEGKA GSGGSRRMEI WCAEIDVGRR GEREIWGKIE WSGTVLTVPN
ESAIVNCLAA TV
