SKIP8_ARATH
ID SKIP8_ARATH Reviewed; 231 AA.
AC Q93YV9; O81622;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=F-box protein SKIP8;
DE AltName: Full=SKP1-interacting partner 8;
GN Name=SKIP8; OrderedLocusNames=At4g10925; ORFNames=F25I24.140, F8M12.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INTERACTION WITH SKP1A/ASK1.
RX PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT Arabidopsis.";
RL Plant J. 34:753-767(2003).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with SKP1A/ASK1. {ECO:0000250,
CC ECO:0000269|PubMed:12795696}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC33952.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g10930 has been split into 2 genes: At4g10925 and At4g10930.; Evidence={ECO:0000305};
CC Sequence=CAB40061.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g10930 has been split into 2 genes: At4g10925 and At4g10930.; Evidence={ECO:0000305};
CC Sequence=CAB81194.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g10930 has been split into 2 genes: At4g10925 and At4g10930.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF080118; AAC33952.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL049525; CAB40061.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161518; CAB81194.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82945.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82946.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82947.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66566.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66567.1; -; Genomic_DNA.
DR EMBL; AY059743; AAL24155.1; -; mRNA.
DR EMBL; AY096714; AAM20348.1; -; mRNA.
DR EMBL; AK117762; BAC42410.1; -; mRNA.
DR EMBL; AY084656; AAM61219.1; -; mRNA.
DR PIR; T01884; T01884.
DR RefSeq; NP_001190698.1; NM_001203769.2.
DR RefSeq; NP_001328452.1; NM_001340692.1.
DR RefSeq; NP_001328453.1; NM_001340693.1.
DR RefSeq; NP_567369.1; NM_117161.4.
DR RefSeq; NP_849357.1; NM_179026.3.
DR AlphaFoldDB; Q93YV9; -.
DR SMR; Q93YV9; -.
DR BioGRID; 11990; 1.
DR STRING; 3702.AT4G10925.3; -.
DR PaxDb; Q93YV9; -.
DR PRIDE; Q93YV9; -.
DR ProteomicsDB; 234587; -.
DR DNASU; 826691; -.
DR EnsemblPlants; AT4G10925.1; AT4G10925.1; AT4G10925.
DR EnsemblPlants; AT4G10925.2; AT4G10925.2; AT4G10925.
DR EnsemblPlants; AT4G10925.3; AT4G10925.3; AT4G10925.
DR EnsemblPlants; AT4G10925.4; AT4G10925.4; AT4G10925.
DR EnsemblPlants; AT4G10925.5; AT4G10925.5; AT4G10925.
DR GeneID; 826691; -.
DR Gramene; AT4G10925.1; AT4G10925.1; AT4G10925.
DR Gramene; AT4G10925.2; AT4G10925.2; AT4G10925.
DR Gramene; AT4G10925.3; AT4G10925.3; AT4G10925.
DR Gramene; AT4G10925.4; AT4G10925.4; AT4G10925.
DR Gramene; AT4G10925.5; AT4G10925.5; AT4G10925.
DR KEGG; ath:AT4G10925; -.
DR Araport; AT4G10925; -.
DR TAIR; locus:505006436; AT4G10925.
DR eggNOG; ENOG502QT1W; Eukaryota.
DR HOGENOM; CLU_084893_0_1_1; -.
DR OMA; VFNWEQG; -.
DR OrthoDB; 1252195at2759; -.
DR PhylomeDB; Q93YV9; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q93YV9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q93YV9; baseline and differential.
DR Genevisible; Q93YV9; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR044260; SKIP8-like.
DR InterPro; IPR037401; SnoaL-like.
DR PANTHER; PTHR47124; PTHR47124; 1.
DR Pfam; PF13474; SnoaL_3; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..231
FT /note="F-box protein SKIP8"
FT /id="PRO_0000375236"
FT DOMAIN 34..80
FT /note="F-box"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 231 AA; 26254 MW; 2A17339207EC0AE3 CRC64;
MPSTPLANGG TPPMGGGERT TVTTSTVADD KPGVSMMEQL VPEITTHALS YLDYPSLCRL
SMTNSLMRKA ANDDNAWKAL YHKDFTLEQD GITPVNGWKE YYATTRAIIS VNTEFFTIIR
DRALQAMARL WLNSDYVKCI HASGELFSGY NEVIQSWQLC FNWEQGFDFQ VHTVRTRILT
DMAWVTMKAY LNVDGGPFLI TNVFEFHNGR WHMVHHHSSV MLIDDQQVVV H
