ID   SKIT1_MACFA             Reviewed;         354 AA.
AC   A0A0E4BZH1;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   24-JUN-2015, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Selection and upkeep of intraepithelial T-cells protein 1;
DE            Short=Skint-1;
GN   Name=SKINT1;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000312|EMBL:BAR64625.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND GENE EVOLUTION.
RX   PubMed=25830554; DOI=10.1371/journal.pone.0123258;
RA   Mohamed R.H., Sutoh Y., Itoh Y., Otsuka N., Miyatake Y., Ogasawara K.,
RA   Kasahara M.;
RT   "The SKINT1-like gene is inactivated in hominoids but not in all primate
RT   species: Implications for the origin of dendritic epidermal T cells.";
RL   PLoS ONE 10:E0123258-E0123258(2015).
CC   -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC       cells in the embryonic thymus. {ECO:0000250|UniProtKB:A7TZE6}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in the thymus and skin.
CC       {ECO:0000269|PubMed:25830554}.
CC   -!- MISCELLANEOUS: All hominoid species have a common inactivating
CC       mutation, but that Old World monkeys such as olive baboons, green
CC       monkeys, cynomolgus macaques and rhesus macaques have apparently
CC       functional SKINT1L sequences, indicating that SKINT1L is inactivated in
CC       a common ancestor of hominoids. {ECO:0000305|PubMed:25830554}.
CC   -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
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DR   EMBL; AB974689; BAR64625.1; -; mRNA.
DR   AlphaFoldDB; A0A0E4BZH1; -.
DR   SMR; A0A0E4BZH1; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..354
FT                   /note="Selection and upkeep of intraepithelial T-cells
FT                   protein 1"
FT                   /id="PRO_0000435873"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          23..141
FT                   /note="Ig-like V-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DOMAIN          161..233
FT                   /note="Ig-like C1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        49..123
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        163..217
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   354 AA;  40540 MW;  A317BA01A500B616 CRC64;
     METAGLSFSR YFVVMNLLQM TIPSSEQFTV NSLERPVLAA LGGNVELSCQ LSPPQSAEHM
     EIRWFRSHYT RPVYLYKEGK DLYGETISKY VERTKLLKEA IGEGKVTLRI LNVSADDDGQ
     YHCFFKDGDV YEEAIAEVKV TATSLEIQIL IHPPNTKGLL VECNSEGWFP QPQMEWRDSR
     GGIIPPSSKS HSQNGNKLFN MKMSLLLRDS SHGNITCYLR NPITGQEERT SIVLSDKLFS
     WDSVWILILV AILAVLLFFI MMPSVELQQR EQRRCCDWNS PCLIGIGIVF SSMCVIIGLT
     ITLHHRNRVP VSDRKFQLVS MYLEDMTVMV WVLMVFITML ISLVYFRLRG FFQI