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SKIT5_MOUSE
ID   SKIT5_MOUSE             Reviewed;        1461 AA.
AC   A7XUY5; A7XUY9; A7XUZ2;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Selection and upkeep of intraepithelial T-cells protein 5;
DE            Short=Skint-5;
DE   Flags: Precursor;
GN   Name=Skint5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J;
RX   PubMed=18408721; DOI=10.1038/ng.108;
RA   Boyden L.M., Lewis J.M., Barbee S.D., Bas A., Girardi M., Hayday A.C.,
RA   Tigelaar R.E., Lifton R.P.;
RT   "Skint1, the prototype of a newly identified immunoglobulin superfamily
RT   gene cluster, positively selects epidermal gammadelta T cells.";
RL   Nat. Genet. 40:656-662(2008).
CC   -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC       cells in the embryonic thymus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=A;
CC         IsoId=A7XUY5-1; Sequence=Displayed;
CC       Name=2; Synonyms=B;
CC         IsoId=A7XUY5-2; Sequence=VSP_034883;
CC       Name=3; Synonyms=C;
CC         IsoId=A7XUY5-3; Sequence=VSP_034884, VSP_034885;
CC   -!- TISSUE SPECIFICITY: Expressed in skin and, to a lower extent, testis.
CC       {ECO:0000269|PubMed:18408721}.
CC   -!- MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered
CC       in the D1 region of the chromosome 4.
CC   -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
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DR   EMBL; EU099301; ABU87899.1; -; mRNA.
DR   EMBL; EU099302; ABU87900.1; -; mRNA.
DR   EMBL; EU099303; ABU87901.1; -; mRNA.
DR   RefSeq; NP_001161348.1; NM_001167876.1. [A7XUY5-1]
DR   RefSeq; NP_001161350.1; NM_001167878.1. [A7XUY5-2]
DR   AlphaFoldDB; A7XUY5; -.
DR   SMR; A7XUY5; -.
DR   BioGRID; 232435; 2.
DR   GlyGen; A7XUY5; 1 site.
DR   iPTMnet; A7XUY5; -.
DR   PhosphoSitePlus; A7XUY5; -.
DR   PaxDb; A7XUY5; -.
DR   PRIDE; A7XUY5; -.
DR   GeneID; 242627; -.
DR   KEGG; mmu:242627; -.
DR   UCSC; uc009vcz.1; mouse. [A7XUY5-1]
DR   UCSC; uc009vda.1; mouse. [A7XUY5-3]
DR   UCSC; uc012diu.1; mouse. [A7XUY5-2]
DR   CTD; 242627; -.
DR   MGI; MGI:3650151; Skint5.
DR   eggNOG; ENOG502SEQH; Eukaryota.
DR   InParanoid; A7XUY5; -.
DR   BioGRID-ORCS; 242627; 2 hits in 34 CRISPR screens.
DR   ChiTaRS; Skint5; mouse.
DR   PRO; PR:A7XUY5; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; A7XUY5; protein.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..1461
FT                   /note="Selection and upkeep of intraepithelial T-cells
FT                   protein 5"
FT                   /id="PRO_5000271637"
FT   TOPO_DOM        25..1306
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1307..1327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1328..1345
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1346..1366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1367..1387
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1388..1408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1409..1427
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1428..1448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1449..1461
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          26..139
FT                   /note="Ig-like V-type"
FT   DOMAIN          142..231
FT                   /note="Ig-like C1-type"
FT   CARBOHYD        200
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..123
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        163..217
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VAR_SEQ         237..257
FT                   /note="VWDSWCPAWIMITLLIVIHMT -> KMCILSSLTATLTHTCYSIPS (in
FT                   isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:18408721"
FT                   /id="VSP_034884"
FT   VAR_SEQ         258..1461
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:18408721"
FT                   /id="VSP_034885"
FT   VAR_SEQ         1235..1255
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:18408721"
FT                   /id="VSP_034883"
SQ   SEQUENCE   1461 AA;  165918 MW;  0131DEB728175728 CRC64;
     MGAVGIPLTA HCVVLFLLQM VALSSEQFTV NGLESPVLVP LDGNLELSCQ LSPPQQAKHM
     EIRWFKNRYS EPVYLYRNGK DLFGEIVYKY VERTELLKDD IGKGKVTLRI FKVTSVDSGS
     YHCFFKDGKF YEEHIIDVKV TATSSDIQIL MHPPNIKGVR LECHSGGWFP QPHMEWRDSK
     GEYIPATSKS HSQDENEFFN MTMDLFIKSN SHWSATCYIQ NFVTHQEESI SIVLPGVWDS
     WCPAWIMITL LIVIHMTYYI KLYRTYATKE MLLKSIQSSS QSSTVDTEKK EWLLKSIQSR
     IQSSSVDAEK KEWLLKFIQS SIQSSSVDLE KKEWLLKSIQ SSIQSAIVDR GTKEWLLESI
     QSSILSSIVD QGTKVLLLKS IQSSIQSSTL DIETKELLLK SIQSSIQSSI MDLGTKELLL
     KIIQSSIQSS SVDLGTKELL LKIIQSSIQS STVDLGTKEL LLKIIQSSIQ SSSVDLGTKE
     LLLKIIQSSI QSSTVDLGTK ELLLKIIQSS IQSSSVDLGA KMGLLESILS SIQSSNVDLE
     TKVLLLKSIQ SSIQSSTVYL GIKQWLLERI ESIIQSSSVY LDTKELLLKI IQSSIESYSV
     DLGNKEFLLK IILSSIQSSS VDLGTKELLV KFFQSNIQSS SVIPGTKKLL VKIIQSSLQS
     SSVDLGTKKV LLDIIQTSIQ NSNVHTERKG LLLKIIQSSV QSSSVDQGTK EMLLEIIQSS
     IQNSSVNQWT KDLLLKIIQS IIQSSSVDLG TKGFLLKIIQ SSIQSSSVDI GTKSMLLKKT
     GLILKSSIVN PGTELLFQLI ESIRHSSSVN SETKKMLSEI TQSTVQSSSV NPVTEEMIEE
     KYQLLLQSSS VNLEAENILN VTTQWILQIS SVNQGKEMLL LDKIQQILQI SSVNPETKDL
     LLEKIELILQ NPGVHQETKD LLLERIQLIL QNSSVQKETK YLLLERIRSI LQSSCVQKET
     KDLLLERIQS LLQSSCVQKE TKDLLLEKIQ LILQNSTVHQ ETKDLLLERI QLFLQNSTVD
     QETSYLLLKR IQLILQSSSV KKETKEFVLY IIESILHSSS VHQETKDLLF DRVQLILESS
     SVQQGLKCLL LNMIQVIFQR TSVQKEMKDL LFNRIPLILE SSSVQQETKD KLLDIIQSIL
     QRTSVQEETK DKLLDIIQSI LQRSSVQKDT IDTLLDRIQL ILQRTSVQKE MKDFLLDRIK
     SILESFSVHQ ETKKLLLNRI MSILESSTVH QETKKLLLER IQSILESSSV QQETKKLLLD
     RIHSILKSSS VQKETKNLLL DRIHSILKSS SVQKESCNKR NPFWKKYALD LGISVFTIIV
     VTLIMHLKQR EADQHFELNT LWSKDTSVIL CVLIMFNNRL KALIYFRLYG FSPPGKAHKY
     IVNYILRFSH PVFCIVYSAT ILYMYLQIQN KDSLFSLYNS WMVEMEMVLI FLLVIFNVKN
     IATVLLYFDS TTLRLFFWIK G
 
 
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