SKIT6_MOUSE
ID SKIT6_MOUSE Reviewed; 1240 AA.
AC A7XUZ6; A7XV01;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Selection and upkeep of intraepithelial T-cells protein 6;
DE Short=Skint-6;
DE Flags: Precursor;
GN Name=Skint6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=18408721; DOI=10.1038/ng.108;
RA Boyden L.M., Lewis J.M., Barbee S.D., Bas A., Girardi M., Hayday A.C.,
RA Tigelaar R.E., Lifton R.P.;
RT "Skint1, the prototype of a newly identified immunoglobulin superfamily
RT gene cluster, positively selects epidermal gammadelta T cells.";
RL Nat. Genet. 40:656-662(2008).
CC -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC cells in the embryonic thymus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=A;
CC IsoId=A7XUZ6-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=A7XUZ6-2; Sequence=VSP_034886, VSP_034887;
CC -!- TISSUE SPECIFICITY: Expressed in skin. {ECO:0000269|PubMed:18408721}.
CC -!- MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered
CC in the D1 region of the chromosome 4.
CC -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU099304; ABU87902.1; -; mRNA.
DR EMBL; EU099305; ABU87903.1; -; mRNA.
DR CCDS; CCDS51269.1; -. [A7XUZ6-1]
DR RefSeq; NP_001096669.1; NM_001103199.1. [A7XUZ6-1]
DR AlphaFoldDB; A7XUZ6; -.
DR SMR; A7XUZ6; -.
DR STRING; 10090.ENSMUSP00000121870; -.
DR GlyGen; A7XUZ6; 3 sites.
DR iPTMnet; A7XUZ6; -.
DR PhosphoSitePlus; A7XUZ6; -.
DR PaxDb; A7XUZ6; -.
DR PRIDE; A7XUZ6; -.
DR Ensembl; ENSMUST00000138966; ENSMUSP00000121870; ENSMUSG00000087194. [A7XUZ6-1]
DR Ensembl; ENSMUST00000171224; ENSMUSP00000132312; ENSMUSG00000087194. [A7XUZ6-1]
DR GeneID; 230622; -.
DR KEGG; mmu:230622; -.
DR UCSC; uc009vcx.1; mouse. [A7XUZ6-1]
DR CTD; 230622; -.
DR MGI; MGI:3649262; Skint6.
DR VEuPathDB; HostDB:ENSMUSG00000087194; -.
DR eggNOG; ENOG502SEQH; Eukaryota.
DR GeneTree; ENSGT00940000162562; -.
DR HOGENOM; CLU_004477_0_0_1; -.
DR InParanoid; A7XUZ6; -.
DR OrthoDB; 1537230at2759; -.
DR PhylomeDB; A7XUZ6; -.
DR TreeFam; TF331083; -.
DR BioGRID-ORCS; 230622; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Skint6; mouse.
DR PRO; PR:A7XUZ6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A7XUZ6; protein.
DR Bgee; ENSMUSG00000087194; Expressed in zone of skin and 4 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1240
FT /note="Selection and upkeep of intraepithelial T-cells
FT protein 6"
FT /id="PRO_5000271640"
FT TOPO_DOM 25..1086
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1087..1107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1108..1125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1126..1146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1147..1167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1168..1188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1189..1205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1206..1226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1227..1240
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 26..141
FT /note="Ig-like V-type"
FT DOMAIN 142..231
FT /note="Ig-like C1-type"
FT CARBOHYD 155
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 314
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 163..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1151..1176
FT /note="YSPPGKTYKYIVNYILRFSQPLFFIV -> KYDGNCVYSENMLHLTKAQMYR
FT RLFL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034886"
FT VAR_SEQ 1177..1240
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034887"
SQ SEQUENCE 1240 AA; 141567 MW; D99F725A9F9823BC CRC64;
MGTIGVPLTA HCVVLFLLQM VALSTEQFTV NGLESPVLVP LGGNLELSCQ LSPPQQAKHM
EIRWFKNRYS EPVYLYRNGK DLNEAIVYKY VERTELLKDD IGKGKVTLRI FKVTSVDSGS
YHCFFKDDKF YEEHIIEVKV TATSSDIQIL MHPPNSTGVR LECHSGGWFP QPHMEWRDSK
GEYIPATSKS HSQDENEFFN MTMDLFIKSN SYWSAACYIQ NFVTHQEESI SFVLPGTKVL
LLKNIQSIFQ SSSVDLEKKD MLLKSIKSRF QSSSVDPEKK ERLLKIIQSR IESSSVDQET
KALLLESIQS SIENSTVDLE TKVWLLESIK SSIQNSSVDP ETKELLLERI KSSIENSTVD
LGTKEWLLES IQSSIQSSSV DLGTKKMLLK IIQSSIQSFS VYIGTKEWLL ERVQSSIQSS
SVDLGTKELL LEIIQSSIEG YSVELGIEEL LSKIILSSIQ SSRVDLGIKE LLVKICQSSI
QSTSVILETK EWLVKIFQSN IQSSSMDLET KVWLVKFFQS SIQSSSMDLG TIKWLVKNVQ
SNIQSSRVDL ETKRMLLEII QSSIQNSSVH RGTKKMLLKV IQSSIQSFSV DLETKEWLLK
IIQSSIQSSS VDIGTKSMLL KKIGLILRSS IVNPGTELLF QIIQSDLQSS SVNTETREML
FEITQPTVQS SSVNSVTEEL LEENYQLLLQ SSSVNLEAEN ILNDTTQRIL QLSSVNQGRE
KLLLDRIQQI LQSSSVNPET KCWLLKRIQF ILENPSVHQE KKDLLLERIH LILQSSSVQK
ETKSLLLGSI QSILHSFSVQ KETKYLLLEK IQLILQNSSV HQETKDLLLK IIQLILQYSS
VHEATSKLLL ERIQLILQSS SVQKETKDLL LNRIFSILQN SCVDQGVKYF LLNIIHPILQ
KTSVHQETKS MLLDRIELIL QSSSMQQETK NHLLDQIEQI LQDTTVHQET KDLLLNRIEL
ILQNSSVQQE TKELLMDKID SILRYTWVHQ ETKDLLLNRI ELILQSSSVQ EETKNFLCNI
IASILQSTSM HQEKKKLLLG RIELILQSSS VQQETKKLLL KIVQSSSPSS SVRLESCNKR
NPFWKKHALD LGISVFAIIV VTLIRHLNQR EADQHFELDT LWSKDTSVIL CVLIMFNNRL
KALIYFRLYG YSPPGKTYKY IVNYILRFSQ PLFFIVYSAI ILVMHLQIQN TDSLFSLYNS
WMVEMIMVLG LLLAIFNVKN IATALLHLGR TTLRLFRIKD
