SKIT7_MOUSE
ID SKIT7_MOUSE Reviewed; 395 AA.
AC A7XV04; A7TZF5; A7TZF6; A7TZF7; A7TZF8; E9Q3C9; M9MMJ4;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Selection and upkeep of intraepithelial T-cells protein 7;
DE Short=Skint-7;
DE Flags: Precursor;
GN Name=Skint7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J, and FVB/NJ;
RX PubMed=18408721; DOI=10.1038/ng.108;
RA Boyden L.M., Lewis J.M., Barbee S.D., Bas A., Girardi M., Hayday A.C.,
RA Tigelaar R.E., Lifton R.P.;
RT "Skint1, the prototype of a newly identified immunoglobulin superfamily
RT gene cluster, positively selects epidermal gammadelta T cells.";
RL Nat. Genet. 40:656-662(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC cells in the embryonic thymus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=A;
CC IsoId=A7XV04-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=A7XV04-2; Sequence=VSP_034888, VSP_034889;
CC Name=3; Synonyms=C;
CC IsoId=A7XV04-3; Sequence=VSP_034890, VSP_034891;
CC -!- TISSUE SPECIFICITY: Expressed in skin, thymus, testis and, to a lower
CC extent, bladder. {ECO:0000269|PubMed:18408721}.
CC -!- MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered
CC in the D1 region of the chromosome 4.
CC -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABS30721.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=ABS30722.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=ABS30723.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=ABS30724.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=ABU87904.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; EF494899; ABS30721.1; ALT_INIT; mRNA.
DR EMBL; EF494900; ABS30722.1; ALT_INIT; mRNA.
DR EMBL; EF494901; ABS30723.1; ALT_INIT; mRNA.
DR EMBL; EF494902; ABS30724.1; ALT_INIT; mRNA.
DR EMBL; EU099306; ABU87904.1; ALT_INIT; mRNA.
DR EMBL; AL627076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX537328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX842671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18475.1; -. [A7XV04-2]
DR CCDS; CCDS51266.1; -. [A7XV04-1]
DR RefSeq; NP_001136247.1; NM_001142775.1. [A7XV04-1]
DR RefSeq; NP_808486.2; NM_177818.3. [A7XV04-2]
DR AlphaFoldDB; A7XV04; -.
DR SMR; A7XV04; -.
DR GlyGen; A7XV04; 2 sites.
DR PaxDb; A7XV04; -.
DR PRIDE; A7XV04; -.
DR DNASU; 328505; -.
DR Ensembl; ENSMUST00000055014; ENSMUSP00000054822; ENSMUSG00000049214. [A7XV04-2]
DR Ensembl; ENSMUST00000163281; ENSMUSP00000127347; ENSMUSG00000049214. [A7XV04-1]
DR GeneID; 328505; -.
DR KEGG; mmu:328505; -.
DR UCSC; uc008udo.1; mouse. [A7XV04-2]
DR UCSC; uc012dio.1; mouse. [A7XV04-1]
DR UCSC; uc029uyq.1; mouse. [A7XV04-3]
DR CTD; 328505; -.
DR MGI; MGI:3041190; Skint7.
DR VEuPathDB; HostDB:ENSMUSG00000049214; -.
DR eggNOG; ENOG502TCM5; Eukaryota.
DR GeneTree; ENSGT00940000164707; -.
DR HOGENOM; CLU_013137_8_4_1; -.
DR InParanoid; A7XV04; -.
DR OMA; QMEWRDN; -.
DR OrthoDB; 814950at2759; -.
DR PhylomeDB; A7XV04; -.
DR BioGRID-ORCS; 328505; 1 hit in 39 CRISPR screens.
DR PRO; PR:A7XV04; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A7XV04; protein.
DR Bgee; ENSMUSG00000049214; Expressed in zone of skin and 9 other tissues.
DR ExpressionAtlas; A7XV04; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..395
FT /note="Selection and upkeep of intraepithelial T-cells
FT protein 7"
FT /id="PRO_5000271642"
FT TOPO_DOM 26..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..329
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..141
FT /note="Ig-like V-type"
FT DOMAIN 142..233
FT /note="Ig-like C1-type"
FT REGION 371..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 163..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 142
FT /note="A -> G (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034890"
FT VAR_SEQ 143..395
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034891"
FT VAR_SEQ 236..252
FT /note="NELFNRDRIWMESLASI -> SEYCHLAWLLIGKQRQK (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034888"
FT VAR_SEQ 253..395
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034889"
FT CONFLICT 7
FT /note="F -> S (in Ref. 1; ABS30722/ABS30724)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="I -> F (in Ref. 1; ABS30722/ABS30724)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="P -> L (in Ref. 1; ABS30722/ABS30724)"
FT /evidence="ECO:0000305"
FT CONFLICT 133
FT /note="A -> V (in Ref. 1; ABS30722/ABS30724)"
FT /evidence="ECO:0000305"
FT CONFLICT A7XV04-2:250..252
FT /note="RQK -> R (in Ref. 1; ABS30722)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 395 AA; 45215 MW; E9D445BBEA42AD50 CRC64;
MMKPEFFCFS GFCVYFLFLQ VVVSSEKLRV TTPTRHLLAR VGGQAELSCQ VIPPHSVMHM
EVRWFRSGHS QPVYLYRGGH KMSEEAAPEY ANRTEFVKEA IGEGKVSLRI HNINILDDGP
YQCSFNGSGF IDAAIMNLNV TAVGLETEIH VQAPDADGVM VECNSGGWFP RPQMEWRDSK
GATLPHSLKS YSQDEARFFY MKMTLLLTNM SHGSIICCIF NPVTGEEKQT SIILANELFN
RDRIWMESLA SIVWIMLSVY ILYIICFYWR TGCASGCLSK CFCVVTSWPV QIVHLLFCTG
TFFAIYLPHR SRVSLSDPQF PLYNNWITEL LFVILFLTIC FALPIILLFI QFQFTSLTKW
EKNKDGIMDQ PRLGKAHETS SLYRKKTGKS WEQEK
