ID   SKIT9_MOUSE             Reviewed;         319 AA.
AC   A7TZG3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Selection and upkeep of intraepithelial T-cells protein 9;
DE            Short=Skint-9;
DE   Flags: Precursor;
GN   Name=Skint9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J;
RX   PubMed=18408721; DOI=10.1038/ng.108;
RA   Boyden L.M., Lewis J.M., Barbee S.D., Bas A., Girardi M., Hayday A.C.,
RA   Tigelaar R.E., Lifton R.P.;
RT   "Skint1, the prototype of a newly identified immunoglobulin superfamily
RT   gene cluster, positively selects epidermal gammadelta T cells.";
RL   Nat. Genet. 40:656-662(2008).
CC   -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC       cells in the embryonic thymus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in skin, thymus and testis.
CC       {ECO:0000269|PubMed:18408721}.
CC   -!- MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered
CC       in the D1 region of the chromosome 4.
CC   -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
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DR   EMBL; EF494907; ABS30729.1; -; mRNA.
DR   CCDS; CCDS38839.1; -.
DR   RefSeq; NP_808532.1; NM_177864.2.
DR   AlphaFoldDB; A7TZG3; -.
DR   SMR; A7TZG3; -.
DR   STRING; 10090.ENSMUSP00000052670; -.
DR   GlyGen; A7TZG3; 1 site.
DR   PaxDb; A7TZG3; -.
DR   PRIDE; A7TZG3; -.
DR   ProteomicsDB; 257025; -.
DR   DNASU; 329918; -.
DR   Ensembl; ENSMUST00000058605; ENSMUSP00000052670; ENSMUSG00000049972.
DR   GeneID; 329918; -.
DR   KEGG; mmu:329918; -.
DR   UCSC; uc008udv.1; mouse.
DR   CTD; 329918; -.
DR   MGI; MGI:3045341; Skint9.
DR   VEuPathDB; HostDB:ENSMUSG00000049972; -.
DR   eggNOG; ENOG502THRH; Eukaryota.
DR   GeneTree; ENSGT00940000165990; -.
DR   HOGENOM; CLU_871423_0_0_1; -.
DR   OrthoDB; 1467692at2759; -.
DR   PhylomeDB; A7TZG3; -.
DR   TreeFam; TF339324; -.
DR   BioGRID-ORCS; 329918; 1 hit in 56 CRISPR screens.
DR   ChiTaRS; Skint9; mouse.
DR   PRO; PR:A7TZG3; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; A7TZG3; protein.
DR   Bgee; ENSMUSG00000049972; Expressed in zone of skin and 3 other tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..319
FT                   /note="Selection and upkeep of intraepithelial T-cells
FT                   protein 9"
FT                   /id="PRO_5000270118"
FT   TOPO_DOM        27..139
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..183
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..228
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          27..117
FT                   /note="Ig-like V-type"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        47..101
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   319 AA;  36119 MW;  F6C67C18AF3DA025 CRC64;
     MESSASCLPG FFMSFLLLQN TVLTQAMRSD IKINIQVPDT EGLLLECTSG SLIPPAEMTW
     RDSNGNIIPH STAFNSQDRD GLLYLKSSIL LKNRAKGPIT CSIYNVTTNQ EKKRSIVLPD
     ALFKSENMSL MSNKFSCPSI YLITIIFLNF LRGILVFCCL RRKPVCFRNL MSTVMEALYS
     KMGVCCLLIW ECLLLVLYIA FLPIYVSFRS RAFLLDDTYP LYTNWLWNIC IILTVIMVLF
     PGLILCLLWT LNCYGQVSSL PPTSMELSTK DSEQNSSKSD DSQENYDVNC KILETCESKI
     FSQHQESCED DTASTLFIS