ID   SKI_AVIES               Reviewed;         437 AA.
AC   P17863;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Transforming protein Ski;
GN   Name=V-SKI;
OS   Avian erythroblastosis virus (strain Sloan-Kettering).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
OX   NCBI_TaxID=11862;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2674685; DOI=10.1128/mcb.9.9.4038-4045.1989;
RA   Stavnezer E., Brodeur D., Brennan L.A.;
RT   "The v-ski oncogene encodes a truncated set of c-ski coding exons with
RT   limited sequence and structural relatedness to v-myc.";
RL   Mol. Cell. Biol. 9:4038-4045(1989).
CC   -!- INTERACTION:
CC       P17863; Q13573: SNW1; Xeno; NbExp=4; IntAct=EBI-6392320, EBI-632715;
CC   -!- SIMILARITY: Belongs to the SKI family. {ECO:0000305}.
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DR   EMBL; M28490; AAA49142.1; -; Genomic_DNA.
DR   PIR; A32574; TVFVSK.
DR   SMR; P17863; -.
DR   IntAct; P17863; 1.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.10.260.20; -; 1.
DR   Gene3D; 3.10.390.10; -; 1.
DR   InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR010919; SAND-like_dom_sf.
DR   InterPro; IPR028760; Ski.
DR   InterPro; IPR003380; SKI/SNO/DAC.
DR   InterPro; IPR037000; Ski_DNA-bd_sf.
DR   InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR   PANTHER; PTHR10005; PTHR10005; 1.
DR   PANTHER; PTHR10005:SF15; PTHR10005:SF15; 1.
DR   Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR   Pfam; PF02437; Ski_Sno; 1.
DR   SMART; SM01046; c-SKI_SMAD_bind; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   SUPFAM; SSF63763; SSF63763; 1.
PE   1: Evidence at protein level;
KW   Oncogene.
FT   CHAIN           1..437
FT                   /note="Transforming protein Ski"
FT                   /id="PRO_0000129386"
FT   REGION          308..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   437 AA;  48868 MW;  A29372928E0036F8 CRC64;
     FHLSSMSSLG GPAAFSARWA QEMYKKDNGK DPAEPVLHLP PIQPPPVMPG PFFMPSDRST
     ERCETILEGE TISCFVVGGE KRLCLPQILN SVLRDFSLQQ INSVCDELHI YCSRCTADQL
     EILKVMGILP FSAPSCGLIT KTDAERLCNA LLYGGTYPPH CKKEFSSTIE LELTEKSFKV
     YHECFGKCKG LLVPELYSNP SAACIQCLDC RLMYPPHKFV VHSHKSLENR TCHWGFDSAN
     WRSYILLSQD YTGKEEKARL GQLLDEMKEK FDYNNKYKRK APRNRESPRV QLRRNKMFKT
     MLWDPAGGSA VLQRQPDGNE VPSDPPASKK TKIDDSASQS PASTEKEKQS SRLRSLSSSS
     NKSIGCVHPR QRLSAFRPWS PAVSANEKEL STHLPALIRD SSFYSYKSFE NAVAPNVALA
     PPAQQKVVSN PPCATVV