ID   SKI_CHICK               Reviewed;         750 AA.
AC   P49140;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Ski oncogene;
DE   AltName: Full=Proto-oncogene c-Ski;
GN   Name=SKI;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2779576; DOI=10.1128/mcb.9.9.4046-4051.1989;
RA   Sutrave P., Hughes S.H.;
RT   "Isolation and characterization of three distinct cDNAs for the chicken c-
RT   ski gene.";
RL   Mol. Cell. Biol. 9:4046-4051(1989).
CC   -!- FUNCTION: May play a role in terminal differentiation of skeletal
CC       muscle cells but not in the determination of cells to the myogenic
CC       lineage. May function in TGF-beta signaling (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       P49140; Q13573: SNW1; Xeno; NbExp=4; IntAct=EBI-6392357, EBI-632715;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the SKI family. {ECO:0000305}.
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DR   EMBL; M28517; AAA48730.1; -; Genomic_DNA.
DR   PIR; A32575; A32575.
DR   PIR; B32575; B32575.
DR   RefSeq; NP_001034407.1; NM_001039318.1.
DR   AlphaFoldDB; P49140; -.
DR   SMR; P49140; -.
DR   BioGRID; 687293; 2.
DR   IntAct; P49140; 1.
DR   STRING; 9031.ENSGALP00000001862; -.
DR   GeneID; 428181; -.
DR   KEGG; gga:428181; -.
DR   CTD; 6497; -.
DR   VEuPathDB; HostDB:geneid_428181; -.
DR   eggNOG; ENOG502QTF6; Eukaryota.
DR   InParanoid; P49140; -.
DR   OrthoDB; 1148296at2759; -.
DR   PhylomeDB; P49140; -.
DR   PRO; PR:P49140; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0005667; C:transcription regulator complex; IMP:AgBase.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IMP:AgBase.
DR   GO; GO:0019904; F:protein domain specific binding; IDA:AgBase.
DR   GO; GO:0042803; F:protein homodimerization activity; IMP:AgBase.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IMP:AgBase.
DR   GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.10.260.20; -; 1.
DR   Gene3D; 3.10.390.10; -; 1.
DR   InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR010919; SAND-like_dom_sf.
DR   InterPro; IPR028760; Ski.
DR   InterPro; IPR003380; SKI/SNO/DAC.
DR   InterPro; IPR037000; Ski_DNA-bd_sf.
DR   InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR   PANTHER; PTHR10005; PTHR10005; 1.
DR   PANTHER; PTHR10005:SF15; PTHR10005:SF15; 1.
DR   Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR   Pfam; PF02437; Ski_Sno; 1.
DR   SMART; SM01046; c-SKI_SMAD_bind; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   SUPFAM; SSF63763; SSF63763; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Nucleus; Proto-oncogene; Reference proteome; Repeat.
FT   CHAIN           1..750
FT                   /note="Ski oncogene"
FT                   /id="PRO_0000129384"
FT   REGION          329..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          727..750
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          558..732
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        353..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..541
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        730..750
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   750 AA;  84282 MW;  01E322EEBE0C402B CRC64;
     METVSRSSFQ PHPGLQKTLE QFHLSSMSSL GGPAAFSARW AQEMYKKDNG KDPAEPVLHL
     PPIQPPPVMP GPFFMPSDRS TERCETILEG ETISCFVVGG EKRLCLPQIL NSVLRDFSLQ
     QINSVCDELH IYCSRCTADQ LEILKVMGIL PFSAPSCGLI TKTDAERLCN ALLYGGTYPP
     HCKKEFSSTI ELELTEKSFK VYHECFGKCK GLLVPELYSN PSAACIQCLD CRLMYPPHKF
     VVHSHKSLEN RTCHWGFDSA NWRSYILLSQ DYTGKEEKAR LGQLLDEMKE KFDYNNKYKR
     KAPRNRESPR VQLRRTKMFK TMLWDPAGGS AVLQRQPDGN EVPSDPPASK KTKIDDSASQ
     SPASTEKEKQ SSWLRSLSSS SNKSIGCVHP RQRLSAFRPW SPAVSANEKE LSTHLPALIR
     DSSFYSYKSF ENAVAPNVAL APPAQQKVVS NPPCATVVSR SSEPPSSAAQ PRKRKHAAET
     PAVPEPVATV TAPEEDKESE AEIEVETREE FTSSLSSLSS PSFTSSSSAK DMSSPGMQAP
     VPVNSSYEVA AHSDSHSSGL EAELEHLRQA LDSGLDTKEA KEKFLHEVVK MRVKQEEKLN
     AALQAKRSLH QELEFLRVAK KEKLREATEA KRNLRKEIER LRAENEKKMK EANESRIRLK
     RELEQARQIR VCDKGCEAGR LRAKYSAQIE DLQVKLQHAE ADREQLRADL MHEREAREHL
     EKVVKELQEQ LWPKSSSQSS SENTTSNMEN