SKOR1_MOUSE
ID SKOR1_MOUSE Reviewed; 964 AA.
AC Q8BX46; B2RQS8; Q3UYA4; Q5W8I2; Q8C0T2;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=SKI family transcriptional corepressor 1;
DE AltName: Full=Fussel-15 homolog;
DE AltName: Full=Ladybird homeobox corepressor 1;
DE AltName: Full=Lbx1 corepressor 1;
DE AltName: Full=Transcriptional corepressor Corl1;
GN Name=Skor1; Synonyms=Corl1 {ECO:0000312|EMBL:BAD69568.1}, Lbxcor1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAD69568.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INTERACTION WITH LBX1.
RC TISSUE=Embryonic brain {ECO:0000269|PubMed:15528197};
RX PubMed=15528197; DOI=10.1074/jbc.m411652200;
RA Mizuhara E., Nakatani T., Minaki Y., Sakamoto Y., Ono Y.;
RT "Corl1, a novel neuronal lineage-specific transcriptional corepressor for
RT the homeodomain transcription factor Lbx1.";
RL J. Biol. Chem. 280:3645-3655(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=17292623; DOI=10.1016/j.mcn.2007.01.002;
RA Arndt S., Poser I., Moser M., Bosserhoff A.-K.;
RT "Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.";
RL Mol. Cell. Neurosci. 34:603-611(2007).
CC -!- FUNCTION: Inhibits BMP signaling (By similarity). Acts as a
CC transcriptional corepressor of LBX1. {ECO:0000250,
CC ECO:0000269|PubMed:15528197}.
CC -!- SUBUNIT: Interacts with SMAD1, SMAD2 and SMAD3 (By similarity).
CC Interacts with LBX1. {ECO:0000250, ECO:0000269|PubMed:15528197}.
CC -!- INTERACTION:
CC Q8BX46; P52955: Lbx1; NbExp=2; IntAct=EBI-604451, EBI-604594;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15528197}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000305};
CC IsoId=Q8BX46-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:15528197};
CC IsoId=Q8BX46-2; Sequence=VSP_014179;
CC -!- TISSUE SPECIFICITY: Expressed in brain with higher levels in embryo
CC than adult. Expressed by migratory precursors of Purkinje cells in the
CC postnatal brain. Also expressed in adult testis.
CC {ECO:0000269|PubMed:15528197, ECO:0000269|PubMed:17292623}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing cerebellum, pons,
CC medulla oblongata and spinal cord. In embryonic brain, expressed in a
CC subset of postmitotic neurons generated posterior to the midbrain-
CC hindbrain border. In the developing spinal cord, selectively expressed
CC in dorsal horn interneurons. {ECO:0000269|PubMed:15528197,
CC ECO:0000269|PubMed:17292623}.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000255}.
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DR EMBL; AB185113; BAD69568.1; -; mRNA.
DR EMBL; AK049035; BAC33520.1; -; mRNA.
DR EMBL; AK134840; BAE22308.1; -; mRNA.
DR EMBL; BC138063; AAI38064.1; -; mRNA.
DR CCDS; CCDS23268.1; -. [Q8BX46-1]
DR CCDS; CCDS52829.1; -. [Q8BX46-2]
DR RefSeq; NP_001157227.1; NM_001163755.1. [Q8BX46-2]
DR RefSeq; NP_001157229.1; NM_001163757.1.
DR RefSeq; NP_766034.2; NM_172446.3. [Q8BX46-1]
DR AlphaFoldDB; Q8BX46; -.
DR SMR; Q8BX46; -.
DR BioGRID; 228910; 5.
DR IntAct; Q8BX46; 5.
DR STRING; 10090.ENSMUSP00000055037; -.
DR iPTMnet; Q8BX46; -.
DR PhosphoSitePlus; Q8BX46; -.
DR MaxQB; Q8BX46; -.
DR PaxDb; Q8BX46; -.
DR PRIDE; Q8BX46; -.
DR ProteomicsDB; 261060; -. [Q8BX46-1]
DR ProteomicsDB; 261061; -. [Q8BX46-2]
DR Antibodypedia; 50926; 27 antibodies from 12 providers.
DR DNASU; 207667; -.
DR Ensembl; ENSMUST00000055281; ENSMUSP00000055037; ENSMUSG00000022245. [Q8BX46-1]
DR Ensembl; ENSMUST00000119146; ENSMUSP00000113924; ENSMUSG00000022245. [Q8BX46-2]
DR GeneID; 207667; -.
DR KEGG; mmu:207667; -.
DR UCSC; uc009qat.2; mouse. [Q8BX46-1]
DR UCSC; uc009qau.2; mouse. [Q8BX46-2]
DR CTD; 390598; -.
DR MGI; MGI:2443473; Skor1.
DR VEuPathDB; HostDB:ENSMUSG00000022245; -.
DR eggNOG; ENOG502QQC2; Eukaryota.
DR GeneTree; ENSGT00940000158440; -.
DR InParanoid; Q8BX46; -.
DR OMA; NFGMLQK; -.
DR OrthoDB; 1034068at2759; -.
DR PhylomeDB; Q8BX46; -.
DR TreeFam; TF324133; -.
DR BioGRID-ORCS; 207667; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8BX46; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BX46; protein.
DR Bgee; ENSMUSG00000022245; Expressed in otolith organ and 64 other tissues.
DR ExpressionAtlas; Q8BX46; baseline and differential.
DR Genevisible; Q8BX46; MM.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0046332; F:SMAD binding; ISO:MGI.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
DR Gene3D; 3.10.260.20; -; 1.
DR Gene3D; 3.10.390.10; -; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR028762; SKOR1.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005; PTHR10005; 1.
DR PANTHER; PTHR10005:SF8; PTHR10005:SF8; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR SUPFAM; SSF63763; SSF63763; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..964
FT /note="SKI family transcriptional corepressor 1"
FT /id="PRO_0000129391"
FT REGION 45..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 853..921
FT /evidence="ECO:0000255"
FT COMPBIAS 48..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..585
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 9..36
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15528197, ECO:0000303|PubMed:16141072"
FT /id="VSP_014179"
FT CONFLICT 934
FT /note="Missing (in Ref. 2; BAE22308)"
FT /evidence="ECO:0000305"
FT CONFLICT 961
FT /note="P -> Q (in Ref. 2; BAC33520)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 964 AA; 100245 MW; B1ECDB458D789E2C CRC64;
MALLCGLGQV TLRLWVPLPF QSENRIGFLA AGAFLRSGGM EALTTQLGPG REGSSSPNSK
QELQPYSGSS ALKPNQVGET SLYGVPIVSL VIDGQERLCL AQISNTLLKN YSYNEIHNRR
VALGITCVQC TPVQLEILRR AGAMPISSRR CGMITKREAE RLCKSFLGEH KPPKLPENFA
FDVVHECAWG SRGSFIPARY NSSRAKCIKC GYCSMYFSPN KFIFHSHRTP DAKYTQPDAA
NFNSWRRHLK LSDKSATDEL SHAWEDVKAM FNGGTRKRTF SLQGGGGGGA NSGSGGAGKG
GAGGGGGPGC GSEMAPGPPP HKSLRCGEDE AAGPPGPPPP HPQRALGLAA AASGPAGPGG
PGGSAGVRSY PVIPVPSKGF GLLQKLPPPL FPHPYGFPTA FGLCPKKDDP VLVAGEPKGG
PGTGSSGGAG TAAGAGGPGA GHLPPGAGPG PGGGTMFWGH QPSGAAKDAA AVAAAAAAAT
VYPTFPMFWP AAGSLPVPPY PAAQSQAKAV AAAVAAAAAA AAAAAGGGGP ESLDGAEPAK
EGSLGTEERC PSALSRGPLD EDGADEALPP SLGPLPPPPP PPARKSSYVS AFRPVVKDAE
SIAKLYGSAR EAYGSGPARG PVPGTGTGGG YVSPDFLSEG SSSYHSASPD VDTADEPEVD
VESNRFPDEE GAQDDTEPRA PSTGGGPDGD QPAGPPSVTS SGADGPTDSA DGDSPRPRRR
LGPPPAIRSA FGDLVADDVV RRTERSPPSG GYELREPCGP LGGPGAAKVY APERDEHVKS
TAVAAALGPA ASYLCTPETH EPDKEDNHST TADDLETRKS FSDQRSVSQP SPANTDRGED
GLTLDVTGTQ LVEKDIENLA REELQKLLLE QMELRKKLER EFQSLKDNFQ DQMKRELAYR
EEMVQQLQIV RDTLCNELDQ ERKARYAIQQ KLKEAHDALH HFSCKMLTPR HCTGNCSFKP
PLLP
