SKOR1_RAT
ID SKOR1_RAT Reviewed; 964 AA.
AC P84551;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=SKI family transcriptional corepressor 1;
DE AltName: Full=Ladybird homeobox corepressor 1;
GN Name=Skor1; Synonyms=Lbxcor1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000269|PubMed:15057822};
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
CC -!- FUNCTION: Inhibits BMP signaling. Acts as a transcriptional corepressor
CC of LBX1 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with LBX1. Interacts with SMAD1, SMAD2 and SMAD3 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AABR03062264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006226487.2; XM_006226425.2.
DR RefSeq; XP_006243308.2; XM_006243246.2.
DR AlphaFoldDB; P84551; -.
DR SMR; P84551; -.
DR STRING; 10116.ENSRNOP00000018756; -.
DR iPTMnet; P84551; -.
DR PhosphoSitePlus; P84551; -.
DR PaxDb; P84551; -.
DR Ensembl; ENSRNOT00000018756; ENSRNOP00000018756; ENSRNOG00000013959.
DR GeneID; 315748; -.
DR UCSC; RGD:1307687; rat.
DR CTD; 390598; -.
DR RGD; 1307687; Skor1.
DR eggNOG; ENOG502QQC2; Eukaryota.
DR GeneTree; ENSGT00940000158440; -.
DR HOGENOM; CLU_011930_1_1_1; -.
DR InParanoid; P84551; -.
DR OMA; NFGMLQK; -.
DR OrthoDB; 1034068at2759; -.
DR PhylomeDB; P84551; -.
DR TreeFam; TF324133; -.
DR PRO; PR:P84551; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000013959; Expressed in cerebellum and 1 other tissue.
DR Genevisible; P84551; RN.
DR GO; GO:0030425; C:dendrite; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0046332; F:SMAD binding; ISO:RGD.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR Gene3D; 3.10.260.20; -; 1.
DR Gene3D; 3.10.390.10; -; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR028762; SKOR1.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005; PTHR10005; 1.
DR PANTHER; PTHR10005:SF8; PTHR10005:SF8; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR SUPFAM; SSF63763; SSF63763; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..964
FT /note="SKI family transcriptional corepressor 1"
FT /id="PRO_0000129392"
FT REGION 45..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 857..921
FT /evidence="ECO:0000255"
FT COMPBIAS 48..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..585
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..672
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 100234 MW; 78D1B922CAB29B7D CRC64;
MALLCGLGQV TLRLWVSLPF QTENRIGFLA AGAFLRSGGM EALTTQLGPG REGSSSPNSK
QELQPYSGSS ALKPNQVGET SLYGVPIVSL VIDGQERLCL AQISNTLLKN YSYNEIHNRR
VALGITCVQC TPVQLEILRR AGAMPISSRR CGMITKREAE RLCKSFLGEH KPPKLPENFA
FDVVHECAWG SRGSFIPARY NSSRAKCIKC GYCSMYFSPN KFIFHSHRTP DAKYTQPDAA
NFNSWRRHLK LSDKSATDEL SHAWEDVKAM FNGGTRKRTF SLQGGGGGGA NSGSGGAGKG
GAGGGGGPGC GSEMAPGPPP HKSLRCGEDE ASGPPGPPPP HPQRALGLAA AANGPAGPGG
PGGSAGVRSY PVIPVPSKGF GLLQKLPPPL FPHPYGFPTA FGLCPKKDDP VLVAGEPKGG
PGTGSGGGAG TAAGAGGPGA GHLPPGAGPG PGGGTMFWGH QPSGAAKDAA AVAAAAAAAT
VYPTFPMFWP AAGSLPVPPY PAAQSQAKAV AAAVAAAAAA AAAAAGGGGP ESLDGAEPAK
EGSLGTEERC PSALSRGPLD EDGADEALPP SLAPLAPPPP PPARKSSYVS AFRPVVKDAE
SIAKLYGSAR EAYGSGPARG PVPGTGTGGG YVSPDFLSEG SSSYHSASPD VDTADEPEVD
VESNRFPDEE GAQEDTEPSV PSTGGGPDGD QPAGPPSVTS SGADGPTDSA DGDSPRPRRR
LGPPPAIRSA FGDLVADDVV RRTERSPPNG GYELREPCGP LGGPAAAKVY VPERDEHVKS
AAAAAALGPA ASYLCTPETH EPDKEDNHST TADDLETRKS FSDQRSVSQP SPANTDRGED
GLTLDVTGTQ LVEKDIENLA REELQKLLLE QMELRKKLER EFQSLKDNFQ DQMKRELAYR
EEMVQQLQIV RDTLCNELDQ ERKARYAIQQ KLKEAHDALH HFSCKMLTPR HCTGNCSFKP
PLLP
