SKOR2_MOUSE
ID SKOR2_MOUSE Reviewed; 1008 AA.
AC A7M7C7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=SKI family transcriptional corepressor 2 {ECO:0000305};
DE AltName: Full=Fussel-18 homolog;
DE AltName: Full=LBX1 corepressor 1-like protein;
DE AltName: Full=Ladybird homeobox corepressor 1-like protein;
DE AltName: Full=Transcriptional corepressor Corl2;
GN Name=Skor2 {ECO:0000312|MGI:MGI:3645984}; Synonyms=Corl2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryonic brain;
RX PubMed=18522874; DOI=10.1016/j.gep.2008.04.004;
RA Minaki Y., Nakatani T., Mizuhara E., Inoue T., Ono Y.;
RT "Identification of a novel transcriptional corepressor, Corl2, as a
RT cerebellar Purkinje cell-selective marker.";
RL Gene Expr. Patterns 8:418-423(2008).
RN [2]
RP DEVELOPMENTAL STAGE.
RX PubMed=16200078; DOI=10.1038/labinvest.3700344;
RA Arndt S., Poser I., Schubert T., Moser M., Bosserhoff A.-K.;
RT "Cloning and functional characterization of a new Ski homolog, Fussel-18,
RT specifically expressed in neuronal tissues.";
RL Lab. Invest. 85:1330-1341(2005).
CC -!- FUNCTION: Acts as a TGF-beta antagonist in the nervous system (By
CC similarity). Exhibits transcriptional repressor activity. {ECO:0000250,
CC ECO:0000269|PubMed:18522874}.
CC -!- SUBUNIT: Interacts with SMAD2 and SMAD3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18522874}. Cytoplasm
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expression is restricted to adult and embryonic
CC central nervous system. Expressed at high levels in the developing
CC cerebellum, ventral metencephalon and myelencephalon at 12.5 dpc (at
CC protein level). In the adult cerebellum, expressed specifically in
CC Purkinje cells. {ECO:0000269|PubMed:18522874}.
CC -!- DEVELOPMENTAL STAGE: First detected at 11 dpc and expression continues
CC into adulthood with higher levels in embryonic than adult brain. In
CC developing brain, not expressed in neural progenitors during the
CC proliferative phase but expression is detected in postmitotic neural
CC precursors shortly after exiting the cell cycle.
CC {ECO:0000269|PubMed:16200078, ECO:0000269|PubMed:18522874}.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000305}.
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DR EMBL; AB358976; BAF76044.1; -; mRNA.
DR CCDS; CCDS50322.1; -.
DR RefSeq; NP_001103213.1; NM_001109743.1.
DR RefSeq; XP_006526499.1; XM_006526436.3.
DR AlphaFoldDB; A7M7C7; -.
DR SMR; A7M7C7; -.
DR STRING; 10090.ENSMUSP00000132338; -.
DR iPTMnet; A7M7C7; -.
DR PhosphoSitePlus; A7M7C7; -.
DR PaxDb; A7M7C7; -.
DR PRIDE; A7M7C7; -.
DR ProteomicsDB; 261406; -.
DR Antibodypedia; 58871; 72 antibodies from 15 providers.
DR Ensembl; ENSMUST00000166956; ENSMUSP00000132338; ENSMUSG00000091519.
DR GeneID; 664805; -.
DR KEGG; mmu:664805; -.
DR UCSC; uc008fqq.1; mouse.
DR CTD; 652991; -.
DR MGI; MGI:3645984; Skor2.
DR VEuPathDB; HostDB:ENSMUSG00000091519; -.
DR eggNOG; ENOG502QQC2; Eukaryota.
DR GeneTree; ENSGT00940000160474; -.
DR HOGENOM; CLU_011930_1_0_1; -.
DR InParanoid; A7M7C7; -.
DR OMA; QLQIVRC; -.
DR OrthoDB; 1034068at2759; -.
DR PhylomeDB; A7M7C7; -.
DR TreeFam; TF324133; -.
DR BioGRID-ORCS; 664805; 1 hit in 73 CRISPR screens.
DR PRO; PR:A7M7C7; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; A7M7C7; protein.
DR Bgee; ENSMUSG00000091519; Expressed in Purkinje cell layer of cerebellar cortex and 9 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IPI:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0046332; F:SMAD binding; IPI:MGI.
DR GO; GO:0048468; P:cell development; IMP:MGI.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
DR GO; GO:0021587; P:cerebellum morphogenesis; IMP:MGI.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IGI:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:MGI.
DR GO; GO:0021936; P:regulation of cerebellar granule cell precursor proliferation; IMP:MGI.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IMP:MGI.
DR GO; GO:1902692; P:regulation of neuroblast proliferation; IMP:MGI.
DR GO; GO:0007224; P:smoothened signaling pathway; IMP:MGI.
DR Gene3D; 3.10.260.20; -; 1.
DR Gene3D; 3.10.390.10; -; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR028376; SKI_corepress_2.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005; PTHR10005; 1.
DR PANTHER; PTHR10005:SF7; PTHR10005:SF7; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR SUPFAM; SSF63763; SSF63763; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1008
FT /note="SKI family transcriptional corepressor 2"
FT /id="PRO_0000334612"
FT REGION 280..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..297
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..539
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..667
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..706
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..738
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..768
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..927
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 105616 MW; 365AD6D63C0D50C4 CRC64;
MASSPLPGPN DILLASPSSA FQPDALSQPR PGHANLKPNQ VGQVILYGIP IVSLVIDGQE
RLCLAQISNT LLKNFSYNEI HNRRVALGIT CVQCTPVQLE ILRRAGAMPI SSRRCGMITK
REAERLCKSF LGENRPPKLP DNFAFDVSHE CAWGCRGSFI PARYNSSRAK CIKCSYCNMY
FSPNKFIFHS HRTPDAKYTQ PDAANFNSWR RHLKLTDKSP QDELVFAWED VKAMFNGGSR
KRALPQPSAH PACHPLSSVK AAAVAAAAAV AGGGGLLGPH LLGAPPPPPP PPPLAELAGA
PHAHHKRPRF DDDDDSLQEA AVVAAASLSA AAASLSVAAA TGGAGPGAGG PGGGCVAGVG
VGASAGAGAA AGTKGPRSYP VIPVPSKGSF GGVLQKFPGC GGLFPHPYTF PAAAAAFGLC
HKKEDAGTAA EALGGAGAGS AGAAPKAGLS GLFWPAGRKD AFYPPFCMFW PPRTPGGLPV
PTYLQPPPQP PSALGCALGD SPALLRQAFL DLAEPGGAGG SAEAAPPPGQ PPPVVANGPG
SGPPATGGTG ARDTLFESPP GGSGGDCSAG STPPAEQGVT SGTGSASSGA GSVGTRVPAP
HHPHLLEGRK AGGGSYHHSS AFRPVGGKDD AESLAKLHGA SAGTPHSAPA HHHHHHHHPH
HHHHHPPQPP SPLLLLQPQP DEPGSERHHP APPPPPPPPP LAPQPHHRGL LSPEGTSCSY
PSEDSSEDEE DEEEEQEVDV EGHKPLEGEE EEDGRDPEDE EEEDEETRVL LGDSLVGGGR
FLQGRGLSEK GSGRDRTTPA VGAFPLALNS SRLLQEDGKL GDSGGSDLPA PPPPPLAPQK
ASSSGGSRPG SPVHHPSLEE EPSYKDNQKP KENNQVIIST KDDNFSDKNK GHGFFITDSD
SSGDFWRERS GEHTQETNSP HSLKKDVENM GKEELQKVLF EQIDLRRRLE QEFQVLKGNT
SFPVFNNFQD QMKRELAYRE EMVQQLQIIP YAASLIRKEK LGAHLSKS
