ID   SKP1_ARTOC              Reviewed;         165 AA.
AC   C5FHU9;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=E3 ubiquitin ligase complex SCF subunit sconC;
DE   AltName: Full=Sulfur controller C;
DE   AltName: Full=Sulfur metabolite repression control protein C;
GN   Name=sconC; Synonyms=skpA; ORFNames=MCYG_01748;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) E3
CC       ubiquitin ligase complexes, which mediate the ubiquitination and
CC       subsequent proteasomal degradation of target proteins. Controls sulfur
CC       metabolite repression, probably by mediating the inactivation or
CC       degradation of the metR transcription factor (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin
CC       ligase complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR   EMBL; DS995702; EEQ28929.1; -; Genomic_DNA.
DR   RefSeq; XP_002848814.1; XM_002848768.1.
DR   AlphaFoldDB; C5FHU9; -.
DR   SMR; C5FHU9; -.
DR   STRING; 63405.XP_002848814.1; -.
DR   EnsemblFungi; EEQ28929; EEQ28929; MCYG_01748.
DR   GeneID; 9227793; -.
DR   eggNOG; KOG1724; Eukaryota.
DR   HOGENOM; CLU_059252_4_0_1; -.
DR   OMA; PLKSADM; -.
DR   OrthoDB; 1412723at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR016897; SKP1.
DR   InterPro; IPR001232; SKP1-like.
DR   InterPro; IPR036296; SKP1-like_dim_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR016072; Skp1_comp_dimer.
DR   InterPro; IPR016073; Skp1_comp_POZ.
DR   PANTHER; PTHR11165; PTHR11165; 1.
DR   Pfam; PF01466; Skp1; 1.
DR   Pfam; PF03931; Skp1_POZ; 1.
DR   PIRSF; PIRSF028729; E3_ubiquit_lig_SCF_Skp; 1.
DR   SMART; SM00512; Skp1; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF81382; SSF81382; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..165
FT                   /note="E3 ubiquitin ligase complex SCF subunit sconC"
FT                   /id="PRO_0000397267"
FT   REGION          106..165
FT                   /note="Interaction with the F-box domain of F-box proteins"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   165 AA;  18766 MW;  80AC8E1D70744D20 CRC64;
     MAATATSKIT LTSSDGVEIT IERQVAERSI LIKNMLEDLG DSGEAIPIPN VNESVLKKVI
     EWCKHHKGDP PSTGDDDVDS RRKTTDIDEW DQKFMQVDQE MLFEIILAAN YLDIKALLDV
     GCKTVANMIK GKSPEEIRKT FNIQNDFTPE EEDQIRRENE WAEDR