ID   SKP1_ARTOT              Reviewed;         165 AA.
AC   Q8TGW7;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=E3 ubiquitin ligase complex SCF subunit sconC;
DE   AltName: Full=Sulfur controller C;
DE   AltName: Full=Sulfur metabolite repression control protein C;
GN   Name=sconC; Synonyms=skpA;
OS   Arthroderma otae (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=63405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND FUNCTION.
RX   PubMed=15922636; DOI=10.1016/j.fgb.2005.04.005;
RA   Uthman A., Dockal M., Soltz-Szots J., Tschachler E.;
RT   "Fluconazole upregulates sconC expression and inhibits sulphur metabolism
RT   in Microsporum canis.";
RL   Fungal Genet. Biol. 42:719-725(2005).
CC   -!- FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) E3
CC       ubiquitin ligase complexes, which mediate the ubiquitination and
CC       subsequent proteasomal degradation of target proteins (By similarity).
CC       Controls sulfur metabolite repression, probably by mediating the
CC       inactivation or degradation of the metR transcription factor.
CC       {ECO:0000250, ECO:0000269|PubMed:15922636}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin
CC       ligase complexes. {ECO:0000250}.
CC   -!- INDUCTION: By fluconazole, an azole-derivative widely used for the
CC       treatment of fungal infections of the skin and its appendages.
CC       {ECO:0000269|PubMed:15922636}.
CC   -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR   EMBL; AF408428; AAL76231.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TGW7; -.
DR   SMR; Q8TGW7; -.
DR   UniPathway; UPA00143; -.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR016897; SKP1.
DR   InterPro; IPR001232; SKP1-like.
DR   InterPro; IPR036296; SKP1-like_dim_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR016072; Skp1_comp_dimer.
DR   InterPro; IPR016073; Skp1_comp_POZ.
DR   PANTHER; PTHR11165; PTHR11165; 1.
DR   Pfam; PF01466; Skp1; 1.
DR   Pfam; PF03931; Skp1_POZ; 1.
DR   PIRSF; PIRSF028729; E3_ubiquit_lig_SCF_Skp; 1.
DR   SMART; SM00512; Skp1; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF81382; SSF81382; 1.
PE   2: Evidence at transcript level;
KW   Ubl conjugation pathway.
FT   CHAIN           1..165
FT                   /note="E3 ubiquitin ligase complex SCF subunit sconC"
FT                   /id="PRO_0000397259"
FT   REGION          106..165
FT                   /note="Interaction with the F-box domain of F-box proteins"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   165 AA;  18707 MW;  BE57EA9A6CCE351D CRC64;
     MAAAATSKIT LTSSDGVDIT IDRQVAERSI LIKNMLKDLG DSGEAIPIPN VNESVLKKVI
     EWCKHHKGDP PSTGDDDVDS RRKTTDIDEW DQKFMQVDQE MLFEIILAAN YLDIKALLDV
     GCKTVANMIK GKSPEEIRKT FNIQNDFTPE EEDQIRRENE WAEDR