SKP1_ASPCL
ID SKP1_ASPCL Reviewed; 159 AA.
AC A1C9U5;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=E3 ubiquitin ligase complex SCF subunit sconC;
DE AltName: Full=Sulfur controller C;
DE AltName: Full=Sulfur metabolite repression control protein C;
GN Name=sconC; Synonyms=skpA; ORFNames=ACLA_009360;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) E3
CC ubiquitin ligase complexes, which mediate the ubiquitination and
CC subsequent proteasomal degradation of target proteins. Controls sulfur
CC metabolite repression, probably by mediating the inactivation or
CC degradation of the metR transcription factor (By similarity).
CC {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin
CC ligase complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SKP1 family. {ECO:0000305}.
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DR EMBL; DS027049; EAW12513.1; -; Genomic_DNA.
DR RefSeq; XP_001273939.1; XM_001273938.1.
DR AlphaFoldDB; A1C9U5; -.
DR SMR; A1C9U5; -.
DR STRING; 5057.CADACLAP00000999; -.
DR EnsemblFungi; EAW12513; EAW12513; ACLA_009360.
DR GeneID; 4706645; -.
DR KEGG; act:ACLA_009360; -.
DR VEuPathDB; FungiDB:ACLA_009360; -.
DR eggNOG; KOG1724; Eukaryota.
DR HOGENOM; CLU_059252_4_0_1; -.
DR OMA; PLKSADM; -.
DR OrthoDB; 1412723at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR016897; SKP1.
DR InterPro; IPR001232; SKP1-like.
DR InterPro; IPR036296; SKP1-like_dim_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR016072; Skp1_comp_dimer.
DR InterPro; IPR016073; Skp1_comp_POZ.
DR PANTHER; PTHR11165; PTHR11165; 1.
DR Pfam; PF01466; Skp1; 1.
DR Pfam; PF03931; Skp1_POZ; 1.
DR PIRSF; PIRSF028729; E3_ubiquit_lig_SCF_Skp; 1.
DR SMART; SM00512; Skp1; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF81382; SSF81382; 1.
PE 3: Inferred from homology;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..159
FT /note="E3 ubiquitin ligase complex SCF subunit sconC"
FT /id="PRO_0000397260"
FT REGION 101..159
FT /note="Interaction with the F-box domain of F-box proteins"
FT /evidence="ECO:0000250"
SQ SEQUENCE 159 AA; 18156 MW; 0DBDE07D99F124AD CRC64;
MSTTVTLTSS DGVDLTVDRD VAERSVLIKN MLEDLGESGE AIPIPNVNEV VLKKVIEWCT
HHKNDPPSTG DDDDSRRKTT DIDEWDQKFM QVDQEMLFEI ILAANYLDIK ALLDVGCKTV
ANMIKGKSPE EIRKTFNIQN DFTPEEEDQI RRENEWAEE
